Based on the annual panel data of 49 countries in the period 2009-2017, this paper empirically analyzes the impact of trade facilitation on high-tech products export. The results suggest that: first, the improvement of trade facilitation has a significant positive impact on high-tech exports; furthermore, the impact of the sub-indices of the trade facilitation level on the high-tech exports ranges from large to small in the order of the port efficiency, e-business, customs environment and regulatory environment; besides, the results of heterogeneity analysis show that the improvement of trade facilitation in non-OECD countries has a significant positive effect on high-tech product exports, in OECD countries the effect is positive but limited. In addition, per capita GDP, the percentage of government expenditure on education, the percentage of gross capital formation, and the proportion of merchandise trade also play a certain role in promoting the export of high-tech products. On the basis of empirical analysis, it is proposed that all countries should consider to promote trade facilitation from the methods of improving infrastructure, e-commerce and customs clearance efficiency; then further improve the quality of the system and the regulatory environment, take actions to encourage and protect the R&D innovation of high-tech enterprises; accelerate the accumulation of human capital of high-tech talents, and thus the export of high-tech products can be promoted.