In the current scenario, the application of remote sensing and GIS has been widely increased in the assessment of water quality. The main aim of this study is to investigate the nature of groundwater and its suitability for domestic and irrigation purpose in Vazhapadi Taluk, Salem district. 50 sample locations are selected in the study area and analysed for 12 basic water quality parameters. The physio-chemical properties are also compared with standard regulations. Based on the detailed investigation in terms of water quality index map is developed using GIS, it is predicted that some sample locations are in need of a primary degree of treatment for domestic usage. The studies also reveal that the majority of groundwater samples are suitable for irrigation purposes.