Perceived differential climate is very common in work by employees in enterprises, and may have a negative impact on the work performance or professional calling of employees. Based on affective event theory and self-regulation theory, this study will investigate the mediating role of affective occupational commitment to bridge above negative effect and will explore the moderating effect of inclusive leadership on the negative effects of perceived differential climate to affective occupational commitment or on the positive effect of affective occupational commitment to professional calling of employees. Questionnaires would be distributed to those employees of Shanton Province in China though QQ or WeChat chattering group. The returned data will be analyzed by SPSS and AMOS software to verify hypotheses in the conceptual framework. It would be expected to provides reference for companies to manage human resource.