抗菌性奈米粒子之製備及其感染性傷口敷料應用

Antibacterial Nanoparticles: Preparation and Infectious Wound Healing Applications

魏詩頵(Shih-Chun Wei)

指導教授 ： 張煥宗

國立臺灣大學/理學院/化學研究所/博士(2021年)

https://doi.org/10.6342/NTU202102105

摘要

傷口癒合是一個動態過程，涉及許多生長因子和細胞因子，在凝血、發炎、增生和重塑的過程中扮演不同的角色。而在傷口處理中最棘手為慢性傷口，經常是慢性病及異常新陳代謝產生癒合延遲或完全停滯，多為停滯於發炎期及增生期。據估計，全世界約有2000萬人患有慢性傷口，其管理和治療費用每年超過300億美元。綜述不同成因造成的慢性傷口皆具有同樣的特性如延長或過度的發炎、傷口感染、形成生物膜 (Biofilm)、產生抗藥菌種甚至減緩傷口癒合能力。本論文主要研究各式不同具有抗菌效果之奈米粒子搭配其他不同方式促進感染型慢性傷口之癒合及略述與其他單位合作之成果。本論文分為五個部分，首先論述慢性傷口特性，抗菌奈米材料發展，而後探討抗藥性金黃色葡萄球菌感染之糖尿病慢性傷口利用複合生長因子及抗菌四級銨之奈米複合材料及兩性分子特性之碳奈米點搭配光動治療皆避免傷口感染及促使癒合增快之研究。

關鍵字

抗菌性奈米粒子 ； 雙功能金奈米粒子 ； 光動碳點微胞 ； 傷口敷料

並列摘要

Wound healing is a dynamic process involving many growth factors and cytokines that play different roles in coagulation, inflammation, proliferation and remodeling. In the wound treatment, the most difficult is chronic wounds, often chronic diseases and abnormal metabolism produce delayed or complete stagnation, mostly stagnant in the inflammatory and proliferative phases. It is estimated that approximately 20 million people worldwide suffer from chronic wounds, and their management and treatment costs exceed $30 billion annually. It is reviewed that chronic wounds caused by different causes have the same characteristics such as prolonged or excessive inflammation, wound infection, formation of biofilm, production of resistant strains and even slowing wound healing. This thesis mainly studies various kinds of nanoparticles with antibacterial effects in combination with other different ways to promote the healing of infectious chronic wounds and to summarize the results of cooperation with other units. This thesis is divided into five parts, firstly discussing the characteristics of chronic wounds, the development of antibacterial nanomaterials, and then exploring the methicillin-resistant Staphylococcus aureus infected chronic wounds using composite growth factors and antibacterial quaternary ammonium nanocomposites or amphiphilic carbon nanodots combined with photodynamic therapy to avoid wound infection and promote the healing in diabetic mice.

並列關鍵字

Antibacterial nanoparticles ； Dual-functional gold nanoparticles ； Photo–responsive C–dot micelle ； Wound healing

參考文獻

1. G. Han, R. Ceilley, Chronic Wound Healing: A Review of Current Management and Treatments, Adv Ther. 2017, 34, 599–610.

2. H. Brem, M. Tomic-Canic, Cellular and molecular basis of wound healing in diabetes, J Clin Invest. 2007, 117, 1219–1222.

3. J. E Grey, K. G Harding, S. Enoch, Venous and arterial leg ulcers, Br. Med. J. 2006, 332, 347–350.

4. N. Raje, C. Dinakar, Overview of Immunodeficiency Disorders, Immunol. Allergy Clin. North Am. 2015, 35, 599–623.

5. J. Wei, L. Meng, X. Hou, C. Qu, B. Wang, Y. Xin, X. Jiang, Radiation-Induced Skin Reactions: Mechanism and Treatment, Cancer Manag. Res. 2019, 11, 167–177.