- 學位論文
環氧壓克力奈米複合樹脂之改質及其應用於抗菌牙科填補材料之研究
Studies on Modified Epoxy Acrylate Nano-composite Resin for Antibacterial Dental Restorative Materials
摘要
本研究以二異氰酸異佛爾酮 (Isophorone diisocyanate, IPDI)及甲基丙烯酸-2-羥基乙酯 (2-Hydroxyethyl methacrylate, HEMA)進行改質環氧樹脂 (Epoxy acrylate, EA)，進而合成出有機改質環氧樹脂HI-EA作為有機樹脂基質 (Resin matrix)，再以奈米氧化鋁(Nano-Al2O3)和奈米二氧化矽(Nano-SiO2)作為無機填充材(Filler)，混摻製備出牙科修復複合樹脂（Dental restorative composite resin）。為了改善繼發性齲齒（Secondary caries）的問題，我們在自行合成之複合樹脂中添加具有抗菌及抗齲齒成分，其中有同時可作為無機填料的釋氟高嶺土 (Fluoride releasing kaolinite)、表沒食子兒茶素沒食子酸酯 (Epigallocatechin gallate, EGCG)以及奈米鋅抗菌液，製備出一系列抗菌牙科複合樹脂，並探討其機械性質以及抗菌性。 本研究主要分為三大部分，第一部分為改質奈米片狀氧化鋁/釋氟高嶺土複合樹脂系列。由實驗結果可知，隨著高嶺土的比例增加，材料的抗菌效果越好，為了提升複合材料的抗菌性，且經由本實驗室發現EGCG具有一定抗菌性，因此，在不影響原本材料的機械性質的情況下，加入EGCG有助於提升材料的抗菌效果。接著再加入1000ug/g之EGCG後，但由於高嶺土質地較軟且無機含量受到限制，在機械性質上較不如預期。 第二部分為了改善複合樹脂的硬度，本研究乃製備出另一系列不同混摻比例之改質奈米二氧化矽/奈米球型氧化鋁，在將其與釋氟高嶺土進行混摻，製備出一系列的抗菌牙科複合樹脂。由於無機填料之含量可以到達70 wt%，此系列有較佳的硬度表現，而且材料在抗菌效果上與第一部分之奈米片狀氧化鋁/釋氟高嶺土複合樹脂系列有一樣的趨勢。 第三部分乃是以奈米鋅作為抗菌成份，在特定比例之改質奈米二氧化矽/奈米球型氧化鋁複合樹脂中，添加不同濃度的奈米鋅抗菌液使複合樹脂具有抗菌性。此系列材料由於無機填料的含量較高，在硬度表現上比市售商品好，添加1000 ppm奈米鋅抗菌液於複合樹脂中後，材料即具有一定的抗菌效果。
並列摘要
In this research, Epoxy acrylate (EA) was modified with isophorone diisocyanate (IPDI) and 2-Hydroxyethyl methacrylate (HEMA) to synthesize HI-EA, which was used as the resin matrix; whereas nano-aluminum oxide (Nano-Al2O3) and nano-silica (Nano-SiO2 ) was used as the inorganic filler to synthesize dental restorative composite resin. In order to overcome the problem of secondary caries, we have added antibacterial and anticavity elements into composite resin. By using materials that can also be used as inorganic filler: fluoride-releasing kaolinite, Epigallocatechin gallate (EGCG), and Nano-zinc antibacterial agent, we produced a series of antibacterial dental composite resins, and furthermore discussed their mechanical properties and antibacterial ability. In the foliated nano-Al2O3/ fluoride-releasing kaolinite series, as the content of the fluoride-releasing kaolinite increased, the antibacterial ability increased too. Also, under the condition of not influencing the mechanical property of the material, adding EGCG improved the antibacterial ability as well. However, due to the texture of kaolinite being quite soft and with limited inorganic content, the result of mechanical property was under expectation. In order to improve the hardness of the self-synthesized composite resins, we produced another series that contained modified nano-SiO2 mixed along with sphered nano-Al2O3 and fluoride-releasing kaolinite. Due to the content of inorganic filler can reach up to 70 wt%, this series has better hardness performance. Also the material has the same antibacterial trend as the foliated nano-Al2O3/ fluoride-releasing kaolinite series. The last part of the research was to use nano-zinc as the antibacterial element to synthesis composite resin. Due to the higher inorganic filler content, this series has a higher performance in hardness compared to products available in the current market. After adding 1000 ppm of nano-zinc antibacterial agent into the composite resin, the materials would have certain antibacterial ability.
參考文獻
延伸閱讀
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