超音波熱手術於乳癌的治療

Ultrasound Thermal Surgery for Breast Tumors

楊士弘(Shih-Hung Yang)

指導教授 ： 林文澧

國立臺灣大學/工學院/醫學工程學研究所/碩士(2004年)

https://doi.org/10.6342/NTU.2004.00831

摘要

本研究提出一套針對乳癌治療的超音波熱手術系統，整個系統是由一個擁有四個區塊的分離聚焦式換能器及結合機械式的掃瞄系統所構成的，我們以電腦模擬系統的加熱圖形，來瞭解本系統是否能有效的對乳癌作熱治療。
在模擬中我們以超音波波場理論為基礎，並結合生物熱傳方程式及熱劑量的公式來建構組織中的加熱情形。模擬結果顯示，當換能器聚焦模式不同時即擁有不同的加熱圖形；當聚焦模式數目增加，加熱圖形就愈大，所需的加熱時間也愈長。我們並結合模式1與模式2的加熱圖形，形成1cm*1cm*2.5cm的加熱圖形，當機械式掃瞄時，可形成2cm*2cm*2cm的加熱圖形。
本研究的貢獻在於系統能組合不同的加熱圖形來適應不同形狀大小的乳癌，與相位陣列式換能器的系統相比，我們所提出的系統架設較簡單，加熱形式較多，且能充分有效利用窗口，因而可治療較大腫瘤。

關鍵字

乳癌 ； 超音波熱手術

並列摘要

In this study, we proposed an ultrasound thermal surgery system for breast tumors. The whole system is composed of a split-focused transducer with four elements and a mechanical scanning system. We simulated a few of heating patterns created by our system to realize that if this system is efficient and appropriate for the treatment of breast tumors.
We used the wave theory, Pennes’ bioheat transfer equation, and thermal dose equivalence in our computer simulation. The results showed that different modes of the transducer can form different kind of heating patterns. With the mode number of transducer increasing, the volume of heating pattern was bigger and the heating time longer. We combined mode 1 and mode 2 to form a 1cm*1cm*2.5cm heating pattern. With mechanical scanning, we could produce a 2cm*2cm*2cm heating pattern.
The superiority of this study is shown that we can combine different heating patterns to match the breast tumor. The heating system is relatively simple and cheap when compared to the 1-D or 2-D phased array systems. In addition, the heating patterns are more variable and the acoustic window is effectively used to treat a larger tumor.

並列關鍵字

breast tumor ； ultrasound thermal surgery

參考文獻

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