利用表面改質以改善聚氨酯導尿管之表面性質

導尿管已成為醫院裡不可或缺的醫療器材。但是目前常用的導尿管會引發多種併發症。導尿管引起的併發症包含插入或拔出時的痛覺、尿道受傷、細菌感染、尿管堵塞，以及凝血或結石。如果長時間使用可能會導致癌症或甚至死亡。許多文獻指出尿管表面的高摩擦力及蛋白質吸附是導致併發症的主要原因。因此要設法降低併發症的發生，尿管表面應該有潤滑塗層以及降低蛋白質吸附的能力。聚氨酯(SPU)導尿管的表面改質設計分為四步驟：氧化，官能基之改善，EDC反應以及水膠交聯。第一步驟是氧化SPU的表面, 使其產生羧基（carboxyl group。第二步驟是利用丙烯酸（acrylic acid）增加更多的表面羧基以達到更好的水膠交聯。第三步驟是讓EDC與SPU表面的羧基反應，進而在下一步與胺基（amine group）反應。最後一步驟是水膠跟改質的表面反應產生氨基（amide bond）。 FTIR 的結果證明每一步驟的有效化學改質成果，水膠塗層不僅高度潤滑(-0.1642 mA AFM, lateral force mode)而且吸附少量的蛋白質(84.1 mg ± 5mg 經過24小時的蛋白質吸收)。此研究證明透過表面改質的SPU具有生物相容性並能抑制細菌的生長，有效解決併發症發生的問題。

關鍵字

聚氨酯；導尿管；表面改質；水膠；蛋白質吸附；抑菌

並列摘要

Currently, urinary catheters pose the risk of complications to any patients who wear them. In long term, these complications may result cancer or even death. Urinary catheter-related complications include discomfort during insertion and removal, urethra injury, bacteria infection, catheter obstruction, such as blood clotting or encrustation. High friction and protein adsorption of urinary catheter have been found to be primary causes of related complications. In order to reduce the risk of these complications, a catheter should have a slippery coating and abilities to minimize protein adsorption. The surface modification of SPU (segmented polyurethane) catheter is designed in four steps: oxidation, functionalities modification, EDC coupling, and hydrogel crosslinking. The first step oxidizes the SPU surface to create carboxyl functionalities. The second step utilizes acrylic acid to generate additional carboxyl functionalities for better crosslinking with hydrogel. The third step is coupling of EDC that will react with carboxyl groups on SPU surface and with amine group of final step. The last step is amide bond formation with amine groups of chitosan in hydrogel. FTIR results verified the chemical reaction of each reaction step. The resulting hydrogel coating not only had high degree of lubricity (-0.1642 mA in lateral force mode of AFM) but also absorbed minimal amount of protein . The surface modified SPU shows more biocompatible, and suppresses bacteria growth as well.

並列關鍵字

segmented polyurethane ； urinary catheter ； surface modification ； hydrogel ； lubricous ； protein adsorption ； antiseptic

參考文獻

1. Lamba, Woodhouse and Stuart L. Cooper. Polyurethanes in Biomedical Applications. Boka Raton: CRC Press LLC, 1998.

3. Mehlika Pulat, Dogan Babayigit. “Surface modification of PU membranes by graft copolymerisation with acrylamide and itaconic acid monomers.” Polymer Testing 2001;20:209-216

4. Tunney, S.P. Gorman. “Evaluation of a poly(vinyl pyrollidone)-coated biomaterials for urological use.” Biomaterials 2002;23:4601-4608

5. Schierholz, Yucel, Rump, Beuth, Gerhard Pulverer. “Antiinfective and encrustation-inhibiting materials-myth and facts.” International Journal of Antimicrobial Agents 2002;19:511-516

6. Wu, Natalie. Personal Interview. 25 July 2004

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利用表面改質以改善聚氨酯導尿管之表面性質

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