The novel PZT-fan design in pseudo-bipolar for a proton exchange membrane fuel cell stack with piezoelectric fan has been developed to generate air supply with high flow rate to initiate the chemical reaction in the cells, and simultaneously push away byproduct e.g. water; that will cause water-flooding within the cells stack. In this design, PEMFC stack contains 24 cm2 of reaction area in six separated fuel cells. This pseudo-bipolar design contained six inside cathodes and six outside anodes to share common piezoelectric fan. The experiment results have shown that the best performance is occurred at the second mode harmonic resonance frequency of piezoelectric fan which used less than 0.15W of power consumption. Relative humidity of hydrogen, cathode chamber thickness and non-piezoelectric blade thickness will affect the PEMFC relative humidity, the indicator of PEMFC performance. The appropriate condition at 50°C for this design is 57.9% of hydrogen relative humidity, 3cm of cathode chamber thickness and 0.1mm of non-piezoelectric blade thickness. In this design, the fuel cell stack with electrical cascade performed better than fuel cell stack with electrical parallel. The results show that maximum power density of PZT fan-PEMFC is 227.5mW/cm2at 2.085Amp. Moreover, the maximum power density shown above is feasible and consistent for approximately one hour in the durability test.