In this thesis, we study the expression of the heat kernel of the Schrodinger operator in Euclidean space and its asymptotic expansion. We start by observing the behavior of the constant coefficient Schr"odinger operator in Euclidean space and introduce the new symbol space, and write down the expression of the heat kernel by the approximation method. It's proved the existence and uniqueness of the heat kernel for the Schr"odinger operator in Euclidean space, and the asymptotic expansion of the heat kernel at time is approach to 0.