新型胺酯壓克力樹酯封填劑：細胞毒性及抗菌性質

在根管治療完成徹底清創之後，根管封填劑配合馬來膠錐體的使用，使根管系統達到滴水不漏的密封。理想的根管封填劑須要有良好的生物相容性並且希望能有抗菌效果。我研究團隊所研發出的胺酯壓克力樹酯封填劑，有良好操作性質並且與聚胺脂錐體材料及牙本質之間的黏著有優於傳統根管封填劑的表現。為了更進一步了解聚胺酯根管封填劑臨床使用的安全性。本研究目的為探討新型胺酯壓克力樹酯封填劑細胞毒性表現及抗菌性質。結果顯示，在細胞毒性測試PC合成的胺酯壓克力樹酯封填劑和市售材料Apexit相較於PBA合成的胺酯壓克力樹酯封填劑及市售材料 EndoREZ、AHplus 及 Tubliseal 有較低的細胞毒性。而在抗菌性質測試中，市售材料AHplus有較高的抗菌效果，胺酯壓克力樹脂封填劑相較於市售材料的抗菌效果低。因此，細胞毒性與抗菌性質是有相關性的，材料抗菌的同時對細胞也會造成影響。而PC合成胺酯壓克力樹酯封填劑具有高轉換率及良好的生物相容性，故極具潛力可以應用於未來的臨床根管治療。

關鍵字

根管封填劑；胺酯壓克力樹酯；細胞毒性；抗菌性質

並列摘要

For sealing off of the root canal system after completely cleaning and shaping, the standard root canal filling is a combination of sealers with gutta-percha cone. The ideal root canal sealer needs good biocompatibility and antibacterial effect. Our research team has developed dual-cured urethane-acrylate (UA) sealer. Theses materials have good handling characteristics and bonding strength. For further research about the safety of urethane-acrylate sealer. The purposes of this study were to investigate the cytotoxicity and antibacterial effect of UA sealer. The results showed the PC-based UA sealer and Apexit have lower cytotoxicity than PBA-based UA sealer and commercial products such as Endorez, AHplus and Tubliseal. In antibacterial effect test, AHplus has higher antibacterial effect and UA sealers have lower antibacterial effect than other commercial products. We conclude that the cytotoxicity and antibacterial effect have correlations, and the higher bactericide effect may also kill the normal cell. PC-based UA sealer with higher conversion rate and good biocompatibility has high potential for clinical use.

並列關鍵字

root canal sealer ； thermoplatic polyurethane ； cytotoxicity ； antibacterial effect

參考文獻

方妍尹 (2010). 新型胺酯壓克力樹酯封填劑：聚合程度、細胞毒性及物理性質. 國立台灣大學牙醫專業學院臨床牙醫研究所碩士論文.

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Ames JM, Loushine RJ, Babb BR et al. (2009) Contemporary methacrylate resin-based root canal sealers exhibit differentdegrees of ex vivo cytotoxicity when cured in their self-cured mode. Journal of Endodontics 35: 225–8.

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新型胺酯壓克力樹酯封填劑：細胞毒性及抗菌性質

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