There are only a handful of companies in the world with over 100 years of history. How century-old enterprises can last through the ages and continue the vitality? Firms are born, they grow, and then they struggle to keep up with changing markets, various companies entered a market in response to a new trend, but quickly engaged in price wars and failed to survive due to lack of innovation. I was fortunate to work at Corning’s new product development department, so began to develop a better understanding of century-old company’s new production development process, and realized that there are superior methodologies that enable a company to operate for over 100 years and continue to remain an industry leader. This study would like to explore the reasons of those century-old businesses to succeed, to know if the innovative management and culture influence company’s performance. Through four century-old businesses’ case study (Corning, 3M, Kodak and Fujifilm), we found some key factors had let century-old enterprises toward prosperous or decline, the every step and decision that company’s management decide would definitely influence business performance in the end. In order to sustain for long, many companies want to catch up with the next generation technologies and products. However, entrepreneurs rarely get their strategies exactly right the first time, some vital factors for those century-old businesses to come up with right strategies and rise again at the critical moments. Culture is key to innovation success. Innovation is not necessary “the amazing invent”, its means “Change”, change for new opportunity. In Corning’s 160 years of history, there have been many examples of technological innovations that helped birth new technology and new products by partnering with giant customers in various industries. There is a technology revolution in semiconductor industry, the semiconductor industry has followed a path defined by Moore's Law for 40 years; 3D IC technology is the next generation of electronics. Corning would like to leverage its core competence to seize this new opportunity with cooperate with giant semiconductor players, and to make the possibilities real.