硫酸鈣生醫陶瓷的燒結行為及其生物降解行為之研究

Effects of additives on the sintering and biodegradation behavior of calcium sulfate

吳浩緯(Hao-Wei Wu)

指導教授 ： 段維新

國立臺灣大學/工學院/材料科學與工程學研究所/碩士(2011年)

https://doi.org/10.6342/NTU.2011.10580

摘要

硫酸鈣(CS)擁有優良的生物特性，被當作骨替代生醫材料已行之有年；而含氧化矽之生醫材料具有活化骨細胞與刺激細胞增殖的能力。因此本實驗以硫酸鈣作為基底材，添加0.1至10 wt% 之不同比例的SiO2當作燒結添加劑，並在900至1200°C下燒結，研究其燒結行為與生物降解行為。再者，CaO、P2O5和NaHCO3等亦當作添加劑，進一步對CS-SiO2二元系統進行改質。本實驗結果顯示，添加劑在少量添加時，對此生醫複合陶瓷的燒結密度影響不大；然而多量添加會降低其燒結密度。XRD結果顯示，添加SiO2會形成矽酸鈣之反應相。當燒結後之硫酸鈣生醫複合陶瓷浸泡於生理食鹽水中，此矽酸鈣會造成生理食鹽水pH值上升。相對於未添加之純硫酸鈣生醫陶瓷，含添加劑之硫酸鈣生醫陶瓷的降解速率明顯降低。此外，此生醫複合陶瓷亦擁有較優異之抗壓強度(155 MPa相對於67 MPa)。本實驗結果顯示，以適當之添加劑可有效改善硫酸鈣的快速降解性與相對較弱之機械性質，並提供一個新的骨替代生醫陶瓷。

關鍵字

硫酸鈣 ； 二氧化矽 ； 燒結 ； 生物降解 ； 抗壓強度

並列摘要

Pure calcium sulfate (CS) is a unique material for its regenerative capability. The silicon-containing biomaterial can activate bone-related gene expression and stimulate cell proliferation. The aim of the present study is to incorporate SiO2 into calcium sulfate and to investigate its effects on sintering and biodegradation behavior. Various amounts of silica, 0.1 to 10 wt%, were added into a calcium sulfate powder and then sintered at 900-1200°C. Moreover, CaO, P2O5 and NaHCO3 were also added to modify the CS-SiO2 system. The addition of a small amount of additives affects little on the density; however, a larger amount of additives reduces the final density after sintering. A reaction phase, calcium silicate, is formed during sintering. The formation of the reaction phase would increase the pH value as the specimens were soaked in normal saline. The biodegradation rate is significantly reduced after the addition of additives. Furthermore, the strength of the composites is higher than that of pure CS (155 MPa and 67 MPa, respectively). These results suggest that the addition of specific additives can improve the properties of CS, and the composite could be a potential candidate for further application as a bone graft biomaterial.

並列關鍵字

calcuim sulfate ； silica ； sintering ； degradation ； compressive strength

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