硫酸鈣/生物活性玻璃複合材的生物降解行為探討

硫酸鈣(CS)具有良好的生物相容性與生物可降解性，因此應用於骨替代生醫材料已行之有年。而含有Na2O-CaO-SiO2-P2O5特定組成的生物活性玻璃，能使材料與骨組織形成良好的鍵結，並刺激骨細胞分化與增殖，進而促進新生骨的形成。本實驗利用噴霧熱解法製備生物活性玻璃，以硫酸鈣為基材，添加1wt%至10wt%不同比例之生物活性玻璃作為燒結添加劑，探討硫酸鈣/生物活性玻璃複合材的燒結行為與生物降解行為。本實驗結果顯示，生物活性玻璃的添加會減緩硫酸鈣的緻密化速率。此外，由微結構觀察可發現到反應相的生成，此反應相會阻礙硫酸鈣的晶粒成長。相較於純硫酸鈣陶瓷，含有5wt%玻璃的硫酸鈣具有較高的抗壓強度。生物活性玻璃的添加亦降低硫酸鈣的降解速率，並維持降解溶液的pH 值接近中性。整體而言，適當之生物活性玻璃的添加可有效改善硫酸鈣的機械性質與降解行為，故此複合材具有良好的潛力，能在骨替代生醫陶瓷領域上有進一步的應用。

關鍵字

硫酸鈣；生物活性玻璃；噴霧熱解製程；燒結；生物降解

並列摘要

Calcium sulfate (CS) exhibits many desired properties to be used as a bone substitute. These properties include biocompatibility and biodegradability. Bioactive glass (BG) demonstrates excellent ability to bond to bone tissue and to stimulate the proliferation of osteoblasts. The combination of these two materials might be of interest. The aim of the present study is to investigate the sintering and biodegradation behavior of calcium sulfate/bioactive glass composites. The bioactive glass is prepared using a spray pyrolysis (SP) process. The amount of glass in composites varies from 1wt% to 10wt%. The sintering was carried out at 600?C to 1200?C. The results demonstrate that the addition of SP-derived bioactive glass reduces the densification rate of calcium sulfate. A reaction phase is formed, which inhibits the growth of CS grains during the sintering. When 5wt% BG is added, the compressive strength of the specimens is enhanced by 30% compared to pure CS specimens. The degradation rate of all CS/BG composites is slower than that of pure CS specimens. Moreover, all composites provide a neutral pH environment during the degradation test. All these results suggest that the addition of bioactive glass can improve the properties of calcium sulfate. The composites investigated in the present study could be used for further application as a bone substitute.

並列關鍵字

calcium sulfate ； bioactive glass ； spray pyrolysis ； sintering ； biodegradation

參考文獻

[1] P. V. Phan, M. Grzanna, J. Chu, A. Polotsky, A. E. Ghannam, D. V. Heerden, D. S. Hungerford and C. G. Frondoza, “The effect of silica-containing calcium-phosphate particles on human osteoblasts in vitro,” J. Biomed. Mater. Res., 67A 1001-1008 (2003)

[2] C. J. Damien and J. R. Parsons, “Bone graft and bone graft substitutes: A review of current technology and application,” J. Appl. Biomater., 2 187-208 (1991)

[3] W. S. Pietrzak, “Calcium sulfate bone void filler: a review and a look ahead,” J. Craniofac. Surg., 11 327-333 (2000)

[4] M. V. Thomas and D. A. Puleo, “Review calcium sulfate: properties and clinical applications,” J. Biomed. Mater. Res. B, 597-610 (2008)

[5] L. L. Hench, “The story of Bioglass?,” J. Mater. Sci.: Mater. Med., 17 967-978 (2006)

國際替代計量

硫酸鈣/生物活性玻璃複合材的生物降解行為探討

全文下載

主題瀏覽