複合磷酸鈣與硫酸鈣生醫材料之降解機制

Degradation Mechanisms of Calcium Phosphate and Sulfate Bio-composites

周上筆(Shang-Bi Chou)

指導教授 ： 薛文景

國立臺北科技大學/工程學院/材料科學與工程研究所/碩士(2011年)

摘要

磷酸鈣與硫酸鈣在骨替代材料之應用上有很好的生物相容性以及可吸收性，植入於人體內有各自的優缺點。本實驗主要將二水磷酸氫鈣與三鈣磷酸鹽粉末依重量比為1:1的比例混合成骨水泥，之後將不同比例的硫酸鈣添加入磷酸鈣骨水泥內，以去離子水作為結合劑製成複合材料。本研究中，對各個不同硫酸鈣含量百分比的複合材料進行探討，其包括固化時間、物理性質、機械性質、微結構觀察。之後浸泡於模擬人工體液內，觀察各個浸泡時間下之各種性質的變化。
實驗結果顯示，隨著硫酸鈣添加量之增加以及含水量的減少，複合材料的固化時間有縮短之現象，且孔隙率會降低以及直徑抗壓強度變大。添加硫酸鈣之複合材料於浸泡實驗後，藉由觀察試片表面的顯微結構，當鈣離子及磷酸根離子濃度達到形成氫氧基磷灰石的飽和濃度，可看到試片表面會形成氫氧基磷灰石。

關鍵字

二水磷酸氫鈣 ； 磷酸鈣 ； 硫酸鈣 ； 氫氧基磷灰石

並列摘要

Having good bio-compatibility and bio-resorption, both calcium phosphate and calcium sulfate conceded their own advantage and disadvantage in the areas of human implantation. In the study, DCPD (dicalcium phosphate dihydrate) and TCP (β tri-calcium phosphate) powders are mixed with equally weight ratio as bony cements were invested systematically. Variation of amounts of calcium sulfate is added into the above CPC (calcium phosphate cement) while using de-ionized water as binder. The composites are analyzed for their harden time, physical properties, mechanical properties, and microstructure. Followed, the characterization of specimens is carried out in the simulated body fluid immersing solution for each interval. The results showed that shorten the harden time and decreased the porosity would enlarge the diametric compressive strength by increasing the added amount of calcium sulfate and decreasing the liquid water content of the composites. The microstructures also indicated that formation of hydroxyapatite is observed on the surfaces of specimens when calcium ions and phosphate ions reach to a saturated concentration.

並列關鍵字

Dicalcium phosphate dihydrate ； Tri-calcium phosphate ； Calcium sulfate ； Hydroxyapatite

參考文獻

[5] 陳維塘，”磷酸鈣骨水泥添加半水石膏之複合材料製備分析用於覆髓治療之研究”，碩士論文，國立台北科技大學材料及資源工程系，台北，2010

[2] Price N., Bendall S. P., Frondoza C., Jinnah R. H., David S. H., “Human osteoblat-like cells （MG63） proliferate on a bioactive glass surface,” John Wiley & Sons, Inc., Vol. 37, 1997, pp. 394-400.

[3] Lange GL, Donath K, “Interface between bone tissue and implants of solid hydroxyapatite or hydroxyapatite-coated titanium implants,” Biomaterials, Bol.10, 1989, p. 121-125.

[6] Coetzee A. S., “Regeneration of bone in the presence of calcium sulfate,” Arch Otolaryngol Vol. 106, 1980, pp. 405-409.

[7] Mckee J. C., Balley B. J., Texas G.., “Calcium Sulfate as a Mandibular Implant. Osteolaryngology- Head and Neck Surgery,” Vol. 92, 1984, pp. 277-286.