磷酸鈣骨水泥添加半水石膏之複合材料製備分析用於覆髓治療之研究

Calcium Phosphate Cement Incorporated with Gypsum for Dental Pulp Capping

陳維塘(Wei-Tang Chan)

指導教授 ： 許淙慶

國立臺北科技大學/工程學院/材料科學與工程研究所/碩士(2010年)

https://doi.org/10.6841/NTUT.2010.00444

摘要

當牙齒受到外力或嚴重二次蛀牙，造成牙髓裸露時，傳統的做法為進行根管治療，將牙髓全部挖除，留下空的根管，補上根管封填材料，再作上人工牙套，此時此顆牙齒為一死亡狀態。現在醫生們希望此顆牙齒為一存活狀態，所以進行覆髓治療，在裸露的牙髓外層，補上一覆髓治療材料，使牙髓不受外界影響。
本研究主要探討磷酸鈣骨水泥添加不同比例之半水石膏的氫氧基磷灰石相變化、微觀結構、固化時間、重量損失、pH值變化、溫度變化、黏度、機械性質、孔隙率及生物相容性。實驗結果顯示，50wt%石膏經過28天，沒有二水石膏之殘留，完全變為氫氧基磷灰石，硬化時間於15分鐘之內，重量損失小於10%，在手術過程中還能保有完整型態，pH值與人體口腔相似，溫度變化最小，黏度明顯比沒加石膏提升，故操作性質良好，初期就能提供適當之機械強度，孔隙率超過40%，有助於細胞浸潤，為毒性很低的材料且具生物適應性。由上述結果顯示，本實驗開發出操作性質良好、硬化時間短且生物相容性良好之複合材料，極具發展潛力用於覆髓治療。

關鍵字

磷酸鈣骨水泥 ； 半水石膏 ； 覆髓治療 ； 短的硬化時間

並列摘要

Human pulp was exposed by trauma or second dental caries seriously. Traditional treatment is root canal treatment. The treatment will remove all human pulp and fill root canal sealing materials. The tooth will be dead. Recently, doctors hope the teeth are vital, so pulp capping therapy will be used. Pulp capping therapy will fill pulp capping materials on exposed pulp. The pulp capping materials will seal the exposed pulp against outside.
The study is focused on discussing the influences of different ratios of calcium sulphate hemihydrates in CPCs on HAP conversion, micro structure, setting time, weight loss, pH value, temperature difference, viscosity, mechanical properties, porosity, and biocompatibility. Results show the 50wt% gypsum/50wt% CPC soaked in PBS 28 days for short setting below 15 ninutes, weight loss below 10wt%, pH value is similar to human, the lowest temperature difference, good handling properties, and good biocompatibility. In summary, the bone cement composite possesses great developing potential to be applied on pulp capping treatment.

並列關鍵字

CPC ； Calcium sulphate hemihydrate ； Pulp capping ； Short setting time

參考文獻

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