摘要
本研究針對人工椎間盤進行磨耗實驗；以一台自行設計的人工椎間盤磨秏試驗機進行。本實驗設定椎間盤以屈曲-伸展14°、側向彎曲±7°以及扭轉±2.5°的運動模式，施加1500±50N的負載，並且將人工椎間盤浸泡於稀釋至25％的血清溶液內，在3Hz的運動頻率下觀察每50萬週期的厚度與重量減少量、試片表面情形並且收集磨屑，持續至250萬週期。 由實驗結果得知，以聚芳醚酮作為核心材料的人工椎間盤在磨耗與變形上比以超高分子量聚乙烯作為核心之人工椎間盤有較好的表現。且實驗結果顯示因半橢圓球面設計而導致接觸面積不足與運動過程有非順應接觸的缺失。此外，加工上精度的要求與表面粗糙度也嚴重影響實驗的結果。 下一階段的人工椎間盤將以半球形面取代半橢圓球面設計，並且需提出加工製造與拋光處理流程，要求表面粗糙度達到 ＝0.05μm以下，使表面間有較平順的接觸行為。 未來可以將人工椎間盤植入動物體內，觀察替代物附近的細胞組織是否有發炎或其他不良反應。
並列摘要
The wear behavior of the artificial intervertebral discs designed in the present work was studied. An intervertebral disc simulator was designed and constructed for performing the experiment. This simulator allows the tested disc make the flexion-extension of 14°, lateral bending of ±7° and rotation of ±2.5° under a cyclic frequency of 3 Hz, exerts a load up to 1500±50N. During a test, the artificial intervertebral disc was soaked in a 25% blood serum solution. The thickness and the weight decrement of the disc were measured and the wear debris was exammed in every five-hundred thousand cycle operation. From the experimental results we find that, using PEEK as the core material of the artificial intervertebral disc is better in the abrasion and the distortion than using UHMWPE. The experimental results also show that the semi-ellipsoidal surface design causes the contact area to wear severely when combined bending and rotating motion took place. In addition, the precision in processes and the surface roughness of the metallic parts were responsible for core wear. The semi-ellipsoidal surface will be replaced by a hemispheroidal surface in the next device design. The required surface roughness of the metallic parts should be as low as ＝0.05μm. In the future, we will try to implant the artificial intervertebral disc into suitable animals in vivo, and observe cellulary tissues nearby the substitute whether will have the inflammation or other bad situation happen.