- 學位論文
以加速磨耗試驗探討關節液成份對聚醚醚酮磨耗顆粒形貌之影響
The Effects of Synovial Fluid Compositions on the Morphology of Poly-Ether-Ether-Ketone(PEEK) Wear Particles by Accelerated Wear Testing
摘要
全人工關節磨耗碎屑所引發的免疫反應，一直是困擾人工關節外科領域的難題。有研究顯示聚醚醚酮已成功的應用在骨科和脊椎病人的臨床表現上，因此本研究利用聚醚醚酮進行加速磨耗試驗，快速測試不同濃度、不同關節液成份對磨耗顆粒形貌的影響，藉此找出生產特定聚醚醚酮磨耗顆粒大小形貌的參數。 利用不同尺寸的微米加工表面，搭配不同濃度組成的關節液分子，我們可以產生出不同形貌的聚醚醚酮磨耗顆粒。實驗結果發現磷脂質濃度對聚醚醚酮磨耗顆粒形貌與磨耗量都沒有顯著的影響。白蛋白濃度對聚醚醚酮磨耗顆粒大小形貌沒有顯著的影響，磨耗量則會隨濃度上升而下降。球蛋白濃度對聚醚醚酮磨耗有很大的影響，球蛋白溶液濃度增加，聚醚醚酮磨耗顆粒大小、長寬比以及磨耗量都會變小，而且三成份當中又以球蛋白所得磨耗量最少。從SEM分析發現，實驗所得聚醚醚酮磨耗顆粒長寬比多在2∼3之間，且磨耗顆粒形狀大小分布都很集中。從實驗數據分析得知，不同的加工表面、潤滑液濃度與成份，對聚醚醚酮磨耗顆粒的磨耗量、大小或形貌上皆有明顯的改變。本實驗結果提供建置可量產特定大小形貌聚醚醚酮磨耗顆粒之平台相關的資訊，為日後進一步的研究，建構有效、快速且安全的前置準備作業。
並列摘要
At present, total joint replacement (TJR) is a widely accepted clinical treatment for orthopedic patients. The invention of artificial joints has indeed solved a lot of problem, but immunological response induced by wear particles of artificial joints thus becomes the difficult problem for joint surgery. Studies have shown that PEEK has been successfully used in the patient's clinical performance of orthopedic and spine. In this study, we applied micro-fabricated surface texture to rub against the PEEK to accelerate the wear rate of PEEK. By changing the concentration of the lubricants, such as albumin, globulin, and phospholipids, we can observe the effects of lubricant concentrations on the morphology of wear particles. The correlations between the morphology of wear particles and lubricant concentrations were summarized. The albumin concentration does not have significantly affected for sizes of PEEK wear particles. But the wear amounts of PEEK increased with increasing albumin concentrations. The sizes, wear amounts and aspect ratios of PEEK wear particles decreased with increasing globulin concentrations. The DPPC concentration does not have significantly affected for morphology and wear amounts of PEEK wear particles. From SEM analysis, the aspect ratios of PEEK wear particles were between 2 to 3, and the distribution ranges were centralized. The results revealed that the micro surface texture, lubricant composition and concentration have a significant impact for the sizes, morphology and wear amounts of PEEK wear particles. The results by this study determine the conditions to produce a large number of specific morphology of PEEK wear particles. For the future further research, we offer effective, fast and safe pre-prepared operation.