關節液成份分子對人工關節材料摩擦行為之影響

The Effects of Synovial Fluid Compositions on the Tribological Behavior of Artificial Joint Materials

施孟琳(Meng-Lin Shih)

指導教授 ： 方旭偉

國立臺北科技大學/工程學院/化學工程研究所/碩士(2007年)

https://doi.org/10.6841/NTUT.2007.00364

摘要

人工關節元件間的磨耗，以致於引起人體免疫反應的磨耗顆粒產生，尤其是超高分子量聚乙烯的磨耗顆粒更是引發一連串的生理反應，造成人工關節損壞的最主要原因。關節運動時，同時會有多種潤滑機制啟動，而不同關節液分子於潤滑時所扮演的功能性也有所不同，多成份關節液分子因彼此分子間會有交互作用關係，亦會造成不同的摩擦機制。因此，我們有必要更深入研究探討關節液成份對於人工關節材料間摩擦的行為，以了解這些關節液分子在摩擦系統中所扮演的角色。
本研究利用摩擦測試系統，對於不同關節液分子白蛋白(albumin)、球蛋白
（globulin）、玻尿酸(hyaluronic acid)、磷脂質(lipid) 及磷脂質添加其他關節液成
份進行摩擦測試。從實驗結果發現磷脂質存在時其摩擦係數為最低，此可能是因
為磷脂質在人工關節材料表面形成一層很穩固的邊界潤滑薄膜，因此降低了摩擦
係數。在磷脂質添加其他關節液中，發現當磷脂質混合白蛋白以及磷脂質混合球
蛋白時，其摩擦係數均較單成分磷脂質存在時高；而磷脂質混合玻尿酸其摩擦係
數較單成分磷脂質存在時低，這可能是因為玻尿酸與磷脂質兩者會藉由極性-極性
的作用力緊密的黏著在一起，進而可潤滑保護兩對磨表面，降低摩擦力。因此未
來我們仍需對關節液分子做研究，以找出最佳潤滑效果的關節液分子。

關鍵字

超高分子量聚乙烯 ； 關節液分子 ； 摩擦性質

並列摘要

The wear of artificial joint elements could lead to the generation of wear debris, triggering immunological reactions in the human bodies. In particular, the UHMWPE particles induce a series of physiological reactions, resulting in the failure of artificial joints. The motion of joints involves several lubrication modes. Different lubricants in the synovial fluid play varying roles in the lubrication mechanisms. Moreover, multi-components in the synovial fluid, which interact with each other, also influence the lubrication ability. Therefore, in order to understand the roles of these lubricants in the synovial fluid, we have to further study the influence of lubricant composition on the tribological behaviors of artificial joints.
In this study, we conducted tribological tests lubricated by albumin, globulin, hyaluronic acid, lipid, and lipid mixed with other components in the synovial fluid. Our results show that the frictional coefficients are lowest when lipid exists in the lubricant. This is probably because lipid forms boundary lubrication films on the surface of artificial joint materials. Compared with the system lubricated by only lipid, lipid mixed with albumin or with globulin shows higher frictional coefficients, and lipid mixed with hyaluronic acid shows lower frictional coefficients. Due to the polar interaction, lipid and hyaluronic acid adhere to each other tightly, lubricate and protect the sliding surfaces, and thus lower the frictional force. In the future, we still need to further study the lubricants in the artificial joints, so that we can find out the best lubricant in the synovial fluid.

並列關鍵字

UHMWPE ； Synovial Fluid ； Friction ； Albumin ； Lipid ； Globulin

參考文獻

蘇毓智，生物潤滑液對超高分子量聚乙烯磨耗行為之影響，碩士論文，國立台北 科技大學生物科技所，台北，2005。

李偉銘，摩擦過程引發生物潤滑液變化對軟骨及人工關節材料摩擦性質之影響， 碩士論文，國立台北科技大學或學工程所，台北，2006。

Adam, N., and Ghosh, P. "Hyaluronan molecular weight and polydispersity in some commercial intra-articular injectable preparations and in synovial fluid." Inflammation Research, vol.50, 2001, pp.294-299.

Affatato, S., Fernandes, B., Tucci, A., Esposito, L., and Toni, A. "Isolation and morphological characterisation of UHMWPE wear debris generated in vitro." Biomaterials, vol.22, 2001, pp.2325-2331.

ASTM F 2003-02 "Standard Guide for Accelerated Aging of Ultra High Molecular Weight Polyethylene." ASTM International 2000.