摩擦過程引發生物潤滑液變化對軟骨及人工關節材料摩擦性質之影響

Effects of Tribological Process induced Transformation of Biological Lubricants on Articualtion of Cartilages and Artificial Joint Materials.

李偉銘(Wei-Ming Lee)

指導教授 ： 方旭偉

國立臺北科技大學/工程學院/化學工程所/碩士(2006年)

https://doi.org/10.6841/NTUT.2006.00232

摘要

生物潤滑液在人體關節中扮演一個重要的角色，使人體關節結構與生物潤滑液的機制中，擁有較小摩擦力的特性。臨床上部份人工膝關節置換手術包含人工關節及正常關節軟骨兩個部份，但是在術後一段時間正常關節軟骨部份容易產生關節炎，因此我們想要探討生物潤滑液在人工關節摩擦過程中是否產生變化，進而影響正常關節軟骨的摩擦性質引發關節炎。
在過去的研究中，總是針對關節軟骨的機械性質來探討關節運動時的摩擦性質，或是關節軟骨的內部結構對摩擦性質造成的影響，對於潤滑液的影響，探討的是關於施加的荷重、時間長短、運動次數等方向來進行研究，較少著重於生物潤滑液在摩擦過程中產生變化對摩擦性質造成的影響，因此我們針對這個觀點來進行研究。
本實驗室自行架設奈米/微米材料表面萬能測試儀與磨耗測試機來進行摩擦測試實驗，觀察生物潤滑液如胎牛血清、白蛋白及玻尿酸、生理緩衝液在摩擦過程中產生的變化是否影響摩擦性質，藉此探討生物潤滑液的摩擦機制。實驗中利用磨耗測試機來製備潤滑液，使用新鮮的潤滑液及經過磨耗過程的潤滑液在兩個表面（ex：UHMWPE、金屬、關節軟骨等）之間充當潤滑液來量測摩擦性質，並觀察其變化，發現摩擦後白蛋白二級結構有明顯的變化，而摩擦力實驗結果顯示，不論是胎牛血清、白蛋白或是玻尿酸，摩擦後的潤滑液比新鮮的潤滑液摩擦係數來得大。

關鍵字

生物潤滑液 ； 摩擦性質 ； 關節軟骨 ； 部份人工膝關節置換手術

並列摘要

Unicompartmental knee arthroplasty and bipolar hemiarthroplasty are two representative partial joint systems. Degeneration in the articulating cartilages is a common cause of failure after the partial joint arthroplasty. Our hypothesis is that the tribochemical reactions of biological lubricants may be related to the cartilage damage. The influence of the tribochemcial reactions of the synovial fluid from the arthroplasty implant interface on the friction properties of the natural cartilage should be investigated.
In this study, in vitro testing procedures have been developed to perfrom the friction measurements for artificial joint and cartilage materials. PBS, Serum, albumin, and hyaluronic acid solutions were the biological lubricants used in this study. The results indicated that the friction coefficients for cartilage articulation increase when the biological lubricant was previously articulated by the artificial joint materials. In addition, a significant change of the secondary structures of the albumin molecule has been observed after the molecules were articulated by the artificial joint materials. We have provided evidence that the tribochemical reaction of biological lubricants lead to the friction increase of articular cartilage.

並列關鍵字

Friction ； Cartilage ； Albumin ； Lubricant ； Tribochemistry

參考文獻

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