Soft errors due to cosmic rays cause an important reliability problem for nano-scale VLSI designs. If we want to develop the related soft error tolerant techniques, first we need to analyze the effect of soft errors at the system level. In this thesis, we propose a pattern-dependent soft error rate computation technique based on cell library characterization for combinational circuits and sequential circuits. We develop a dynamic soft error rate simulator. We use benchmark circuits from ISCAS’89 and ITC’99 to compare our proposed technique with HSpice simulation. Our proposed technique is 5 ~ 6 orders of magnitude speed-up over HSpice simulation with less than 3% error.