過度表現 Sonic hedgehog 訊息導致斑馬魚皮膚癌化之分子機轉探討

Sonic hedgehog signaling promotes cell cycle progression and consequently causes epidermis dysplasia of the zebrafish embryos

游宗翰(Tsung-Han Yu)

指導教授 ： 陳曜鴻

淡江大學/理學院/生命科學研究所碩士班/碩士(2007年)

https://doi.org/10.6846/TKU.2007.01168

摘要

本篇摘要未授權

關鍵字

斑馬魚 ； 基因轉殖 ； 皮膚癌

並列摘要

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並列關鍵字

Shh ； Zebrafish ； RFP ； Basal cell carcinomas ； Transgenic fish ； Skin cancer

參考文獻

Aszterbaum, M., Beech, J., and Epstein, E. H., Jr. (1999). Ultraviolet radiation mutagenesis of hedgehog pathway genes in basal cell carcinomas. J Investig Dermatol Symp Proc 4, 41-45.

Athar, M., Tang, X., Lee, J. L., Kopelovich, L., and Kim, A. L. (2006). Hedgehog signalling in skin development and cancer. Exp Dermatol 15, 667-677.

Booth, D. R. (1999). The hedgehog signalling pathway and its role in basal cell carcinoma. Cancer Metastasis Rev 18, 261-284.

Botchkarev, V. A., and Fessing, M. Y. (2005). Edar signaling in the control of hair follicle development. J Investig Dermatol Symp Proc 10, 247-251.

Byrd, N., and Grabel, L. (2004). Hedgehog signaling in murine vasculogenesis and angiogenesis. Trends Cardiovasc Med 14, 308-313.