聚碸/矽酸鈣複合材料之機械性質與生物降解性

Mechanical properties and biodegradability of polysulfone/calcium silicate composites

蔣蕙宇(Huei-Yu Jiang)

指導教授 ： 丁信智

中山醫學大學/口腔醫學院/口腔科學研究所/碩士(2022年)

https://doi.org/10.6834/csmu202200259

摘要

現今骨科與牙科經常使用鈦或氧化鋯的植入物，但由於鈦和氧化鋯的彈性係數都遠高於人體皮質骨(皮質骨7-30 GPa、鈦102 GPa、氧化鋯200 GPa)，會產生應力遮蔽導致手術的失敗。為了改善此問題，因此需要開發新型的植入物材料，應用在骨科手術中。聚碸有良好的機械強度以及熱穩定性，但由於其生物惰性導致應用受限。因此，本實驗使用二種聚碸材料，添加矽酸鈣熱處理以製備複合材料，進行表面分析及機械強度測試，並透過體外生物浸泡評估生物降解性。研究結果顯示聚碸經過熱處理後，三點彎曲強度由39.5 MPa增加至109.3 MPa，拉伸強度由4.6 MPa增加至63.2 MPa，然而抗壓強度則由48 MPa略減少至46 MPa。拉伸強度彈性係數由0.8 GPa增加至1.86 GPa。相對之下，聚碸/矽酸鈣比為7:3，三點彎曲強度未熱處理的39.5 MPa下降至5.4 MPa、拉伸強度由4.6 MPa下降至0.8 MPa、抗壓強度由48 MPa降低至38.61 MPa，拉伸強度彈性係數則由0.95 GPa降低至0.37 GPa。SEM影像觀察奈米析出聚碸顆粒大小為50-100 nm，矽酸鈣顆粒大小為100 nm。XRD及FTIR均顯示聚碸晶相結構與官能基均不受矽酸鈣添加影響。經過SBF體外浸泡一個月後XRD顯示，聚碸/矽酸鈣比為7:3時，在2θ=32˚發現HA主要特徵峰；在三個月時，8:2與7:3比例均在2θ=26與32˚發現HA特徵峰，此結果證實複合材料具有形成HA能力，並且當矽酸鈣含量較高時，形成HA所需時間較少。重量損失結果顯示聚碸/矽酸鈣8:2與7:3與浸泡一個月相比，浸泡三個月後重量上升。綜上所述，在聚碸/矽酸鈣比為8:2且熱處理溫度為240℃時，抗壓強度(69-95 MPa)與彈性係數(2.8 GPa)等機械性質，以及生物降解性評估均較9:1與7:3兩組優異。

關鍵字

聚碸 ； 矽酸鈣 ； 植入物 ； 複合材料

並列摘要

Nowadays, implants of titanium or zirconia are often used in orthopedics and dentistry, but since the elastic coefficients of titanium and zirconia are much higher than those of human cortical bone. The resulting stress shielding leads to the failure of the surgery. In order to improve this problem, it is necessary to develop new implant materials for orthopedic surgery. Polysulfone has good mechanical strength and thermal stability, but its application is limited due to its biological inertness. Therefore, in this experiment, two kinds of polysulfone materials were used, and calcium silicate was added for heat treatment to prepare composite materials. Surface analysis and mechanical strength tests were performed, and biodegradability was evaluated by in vitro bioimmersion. The research results show that after heat treatment, the three-point flexural strength increases from 39.5 MPa to 109.3 MPa, the tensile strength increases from 4.6 MPa to 63.2 MPa, but the compressive strength decreases slightly from 48 MPa to 46 MPa. The elastic modulus of tensile strength increased from 0.8 GPa to 1.86 GPa. In contrast, when the ratio of polysulfone/calcium silicate is 7:3, the three-point bending strength decreases from 39.5 MPa to 5.4 MPa without heat treatment, the tensile strength decreases from 4.6 MPa to 0.8 MPa, and the compressive strength decreases from 48 MPa to 38.61 MPa. MPa, the elastic modulus of tensile strength decreased from 0.95 GPa to 0.37 GPa. The particle size of nano-precipitated polysulfone was 50-100 nm, and the particle size of calcium silicate was 100 nm. Both XRD and FTIR showed that the crystal phase structure and functional groups of polysulfone were not affected by the addition of calcium silicate. After soaking in SBF for one month in vitro, XRD showed that when the ratio of polysulfone/calcium silicate was 7:3, the main characteristic peak of HA was found at 2θ=32°; at three months, the ratios of 8:2 and 7:3 were both in the The characteristic peaks of HA were found at 2θ=26 and 32°, which confirmed that the composite material had the ability to form HA, and when the calcium silicate content was higher, the time required to form HA was less. The weight loss results showed that the weight of polysulfone/calcium silicate 8:2 and 7:3 increased after soaking for three months compared with soaking for one month. To sum up, when the ratio of polysulfone/calcium silicate is 8:2 and the heat treatment temperature is 240 °C, the mechanical properties such as compressive strength (69-95 MPa) and elastic coefficient (2.8 GPa) and biodegradability evaluation are all good. It is better than the 9:1 and 7:3 groups.

並列關鍵字

polysulfone ； calcium silicate ； implants ； composite

參考文獻

參考文獻

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