益生菌對於全身性紅斑性狼瘡小鼠的影響

The impact of probiotics for Systemic Lupus Erythematosus mice

許國清(Kuo-Ching Hsu)

指導教授 ： 曾博修

中山醫學大學/醫學院/生化暨生物科技研究所/碩士(2012年)

https://doi.org/10.6834/CSMU.2012.00016

摘要

全身性紅斑性狼瘡(systemic lupus erythematosus,SLE)是一種自體免疫性疾病，由於遺傳、感染、環境、內分泌因素交互作用而引發免疫系統失去平衡，將自身體細胞當作抗原，產生自體抗體，自體抗體會進入細胞和胞器結合，引發免疫反應，破壞細胞，造成大量細胞碎片，同時也產生出大量免疫復合物，順著血液流動至全身，造成全身性的慢性發炎，並且會啟動發炎相關訊息路徑產生發炎反應，影響細胞的增生和分化能力。自體抗體會在全身順著血液流動，產生病變，在肝臟，自體抗體會將肝細胞辨識，引起免疫性肝炎，免疫性肝炎會引發肝硬化、肝腫大、膽囊阻塞，在自體免疫疾病上的治療視為重要的關鍵，由於免疫性肝炎會使疾病的進程加速，減緩治療的效果，同時也會影響病患的生活作習，因此在目前在自體免疫性疾病的治療上都會針對免疫性肝炎作為首先的治療目標。在本篇研究中我們以具有全身性紅斑性狼瘡小鼠模擬病患，餵食六個月益生菌之後，取出肝臟分析益生菌對於全身性紅斑性狼瘡小鼠肝臟發炎病情影響，而在結果中可以觀察到，原本上升的發炎相關細胞激素，在餵食益生菌之後可以有效的降低發炎相關細胞激素，進一步去影響發發炎相關訊息路徑中相關蛋白的表現，減緩發炎的情形， 因此益生菌可以有效的減緩自體免疫性肝炎的病情，改善全身性紅斑性狼瘡的治療上的困難

關鍵字

益生菌 ； 全身性紅斑性狼瘡

並列摘要

Systemic lupus erythematosus is an autoimmune disease, due to genetic, infectious, environmental, and endocrine factors interact and lead to immune function disordered, abnormal lymphocytes, will mistaken for self cells to produce autoantibodies autoantibodies into the cellular organelles to trigger an immune response, damage cells, resulting in a large number of cell debris, but also produce a large number of immune complexes along the blood flow throughout the body, causing chronic inflammation of the systemic inflammatory signaling pathways, and will start produce inflammation, affect cell proliferation and differentiation. Autoantibodies in systemic down blood flow, resulting in lesions in the liver, the liver cells since the antibody identification, causing autoimmune hepatitis, autoimmune hepatitis will lead to cirrhosis, hepatomegaly, gallbladder obstruction, autoimmune regarded as an important key to the treatment of diseases, due to the disease process of autoimmune hepatitis will accelerate, slow down the effects of treatment, but also affect the patient's living habits, in the treatment of autoimmune diseases will as the first treatment target for autoimmune hepatitis. In this study, we fed six months of probiotics to patients with systemic lupus erythematosus mice simulation, remove the liver, inflammation of the liver disease impact for systemic lupus erythematosus in mice, and in the results can observed that the original increase in inflammatory cytokines, after feeding probiotics can effectively reduce inflammation-related cytokines, and further to influence the performance of related proteins in the fat inflammation in the message path, slowing the case of inflammation, so probiotics can effectively slow down the disease, autoimmune hepatitis and to improve the difficulties in the treatment of systemic lupus erythematosus

並列關鍵字

Systemic Lupus Erythematosus ； probiotics

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