骨盆腔發炎患者其罹患婦癌及泌尿道癌之風險研究

Study of the gynecologic and urinary tract cancer risk with pelvic inflammatory disease

林惠文(Hui-Wen Lin)

指導教授 ： 楊順發

中山醫學大學/醫學院/醫學研究所/博士(2019年)

https://doi.org/10.6834/CSMU201900140

摘要

本篇研究主要目標為確認骨盆腔發炎疾病 (pelvic inflammatory disease, PID) 與乳癌、結直腸癌、婦科癌症以及尿道癌之間的關係。本研究數據來源是來自國家健康保險計劃所收集之縱向健康保險數據庫2000 (Longitudinal Health Insurance Database 2000, LHID 2000) 所編制的縱向數據集。我們取樣了自2000年至2013年間被診斷出骨盆腔發炎，且至少進行了兩次門診就診以及一次入院之病例，另外也獲得了年齡相符，且在2000年至2013年間並未被診斷出骨盆腔發炎的女性，作為對照組。骨盆腔發炎患者與對照組的異位妊娠發生率 (每萬人/月) 分別為1.912與0.595，而其發病倍率為3.211倍。我們也發現骨盆腔發炎患者與對照組之間，在婦科癌症以及尿道癌的發生率方面存在顯著差異，但與結直腸癌或乳癌則無顯著相關性。然而透過了解骨盆腔發炎流行病學以及控制發炎反應，也許未來可以針對這方面達成癌症預防以及合理的醫療資源運用。

關鍵字

乳癌 ； 結直腸癌 ； 婦科癌症 ； 尿道癌 ； 骨盆腔發炎

並列摘要

The aim of the study was to determine the association between pelvic inflammatory disease (PID) and breast, colorectal, gynecologic and urinary tract cancers. The source of data was a longitudinal dataset compiled by the Longitudinal Health Insurance Database 2000 (LHID 2000) which was collected by the National Health Insurance program. Cases of PID, at least two outpatient visits and one admission, were diagnosed from 2000 to 2013. The data for controls, age matched women who were not diagnosed with PID from 2000 to 2013, were also obtained. The ectopic pregnancy incidence rate (per 10000 person months) was 1.912 and 0.595 in the PID and control group, respectively and the rate ratio was 3.211. There were significantly different in gynecologic cancers and urinary tract cancers between the PID and control group but not colorectal or breast cancer. The information may lead to a strategy for cancer prevention and a reasonable healthcare usage through understanding PID epidemiology and controlling the inflammatory responses.

並列關鍵字

breast cancer ； colorectal cancer ； gynecologic cancer ； urinary tract cancer ； PID

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