類風濕性關節炎患者之類風濕性關節炎因子效價及其臨床相關性

Significance of RF titer and clinical profile in patients with Rheumatoid Arthritis

劉宜璟(Yi-Jiing Liu)

指導教授 ： 蔡淦仁

中山醫學大學/醫學院/生化暨生物科技研究所/碩士(2006年)

摘要

類風濕性關節炎 (Rheumatoid Arthritis；RA) 是一種自體免疫的慢性多系統
疾病，其詳細致病機轉仍未完全了解。雖然有多種不同的全身性表現，但類風
濕性關節炎的病變特徵是持續性的滑膜炎，通常累及對稱的周圍關節。滑膜炎
能引起軟骨破壞和骨侵蝕，最後引起關節畸形是為該疾病的主要標誌。臨床上
診斷類風濕性關節炎除了臨床表徵的診斷依據外，除類風濕因子(Rheumatoid
Factor；RF；一種與IgG的Fc片段能起反應的自身抗體)外，目前並無特異性檢
查方法。在本論文研究中，乃針對多種多樣不同類型的類風濕性關節炎，在使
用較為基本用藥狀況下的症狀改善情形、及檢驗室傳統的相關檢查項目，如：
血液血球全套檢查、紅血球沉澱速率 (Erythrocyte Sedimentation Rate；ESR)、
C-反應性蛋白定量 (CRP quantitative)、及類風濕關節炎因子(RF quantitative)間
的比較，並探討其間的關聯性，與類風濕性關節炎疾病發展的關係。

關鍵字

類風濕性關節炎 ； 類風濕性關節炎因子

並列摘要

Rheumatoid Arthritis(RA) is an autoimmunologically and multi-systemically chronic disease which is not fully understood its aetiology and pathogenesis. One of the most distinctive characteristics of RA is its continous synovitis which commonly affects most of the symmetric joints. Synovitis due to RA usually leads to cartilage destruction and bone erosion followed by joint deformity, if not being properly controlled. The destructiveness of RA presents in many forms, some patients with mild and transient arthralgia, however severe arthralgia is frequently found in most of these RA patients. So far, aside from the clinical signs and symptoms,the laboratory test for Rheumatoid Factor(RF), an autoantibody which reacts to the Fc fragment of IgG, still be the criterion for the diagnosis of RA. Other laboratory findings including complete blood count(CBC), erythrocyte sedimentation rate(ESR), and C-Reactive Protein(CRP), alone with the RF level, are continuous decline when RA symptoms are released. In this thesis study, we evaluated the potential usages of these laboratory tests for RA diagnosis, and their correlations with the severities of the disease were also discussed.

並列關鍵字

Rheumatoid arthrititis ； Rheumatoid Factor

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