Metabolic Syndrome in Patients with Rheumatoid Arthritis: Association of Lifestyle with Anthropometric Measurements

類風濕性關節炎病人的代謝症候群與生活習慣及體位測量相關性之研究

陳銘夫(Ming-Fu Chen) ； 陳一銘(Yi-Ming Chen) ； 陳得源(Der-Yuan Chen) ； 藍忠亮(Joung-Liang Lan)

《Formosan Journal of Rheumatology》 24卷1&2期 (2010/12) Pp. 64-71

https://doi.org/10.6313/FJR.2010.24(1-2).10

摘要

Objective: Metabolic syndrome (MS) is a clustering of major risk factors for the occurrence of cardiovascular disease (CVD). Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with an increased CVD risk. In this prospective study, we evaluated the rate of MS and the association of lifestyle with anthropometric measurements in RA patients.
Method: We enrolled 86 RA patients who attended a hypertension, hyperglycemia, hyperlipidemia questionnaire assessment clinic between December 2008 and June 2009. In addition, we randomly selected 172 age- and sex-matched controls from the database of the Bureau of Health Promotion, the Department of Health, in Taiwan.
Results: The rate of MS was higher in RA patients (26.7%) than in controls (22.1%), but there was no statistical significance. A significantly higher DAS28 was observed in RA patients with MS than in those without MS (4.66±0.17 vs. 4.00±0.12, p＜0.05). Significantly higher levels of total cholesterol, HDL-C, and systolic blood pressure, and significantly lower levels of fasting glucose, LDL-C and TG were observed in RA patients than in controls. The occurrence rate of family history of diabetes and hypertension was higher in RA patients with MS than in those without MS.
Conclusion: Chronic inflammation status of RA plays an important role in the risk of developing MS. Our results suggest that RA patients should be control their disease activity aggressively.

關鍵字

代謝症候群 ； 類風濕性關節炎 ； 生活習慣 ； 體位測量

並列摘要

Objective: Metabolic syndrome (MS) is a clustering of major risk factors for the occurrence of cardiovascular disease (CVD). Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with an increased CVD risk. In this prospective study, we evaluated the rate of MS and the association of lifestyle with anthropometric measurements in RA patients.
Method: We enrolled 86 RA patients who attended a hypertension, hyperglycemia, hyperlipidemia questionnaire assessment clinic between December 2008 and June 2009. In addition, we randomly selected 172 age- and sex-matched controls from the database of the Bureau of Health Promotion, the Department of Health, in Taiwan.
Results: The rate of MS was higher in RA patients (26.7%) than in controls (22.1%), but there was no statistical significance. A significantly higher DAS28 was observed in RA patients with MS than in those without MS (4.66±0.17 vs. 4.00±0.12, p＜0.05). Significantly higher levels of total cholesterol, HDL-C, and systolic blood pressure, and significantly lower levels of fasting glucose, LDL-C and TG were observed in RA patients than in controls. The occurrence rate of family history of diabetes and hypertension was higher in RA patients with MS than in those without MS.
Conclusion: Chronic inflammation status of RA plays an important role in the risk of developing MS. Our results suggest that RA patients should be control their disease activity aggressively.

並列關鍵字

Metabolic syndrome ； rheumatoid arthritis ； lifestyle ； anthropometric measurements