山藥紅麴調降血脂之研究

Reduction of plasma lipid by red mold dioscorea

劉勝福(Sheng-Fu Liu)

指導教授 ： 王進崑

中山醫學大學/健康管理學院/營養學研究所/碩士(2015年)

https://doi.org/10.6834/CSMU.2015.00097

摘要

根據2014年世界衛生組織統計，全球最大死因是缺血性心臟病。心臟病與動脈粥狀硬化以及高血脂有明顯關聯性。降低膽固醇可有效地減少高血脂的發生。在東亞，紅麴米( red mold rice；RMR )是一種常見的調節血脂保健食品。NTU568，本紅麴產品是以山藥做為發酵的原料，即「山藥紅麴」(red mold dioscorea；RMD)。本研究中，以人體臨床試驗來探討山藥紅麴調節血脂之功能性，共納入40位受測者隨機分配至兩群組中(試驗組與安慰劑組)。本研究納入條件為總膽固醇大於180 mg/dl且三酸甘油酯介於130-190 mg/dl之間，且無服用降血脂藥之成年人 (20~65歲)。受試者每天飯後吃一顆山藥紅麴膠囊(重0.5克)或安慰劑。本試驗有2週的穩定期，試驗期 8週，追蹤期4週，分別在第0, 2, 6, 10, 14 週採集血液樣本進行生化分析並紀錄相關變化。檢測受測者體重、體脂肪、血壓，並採血測定三酸甘油酯、總膽固醇、低密度脂蛋白膽固醇 (low density lipoprotein cholesterol；LDL-C)、高密度脂蛋白膽固醇 (high density lipoprotein cholesterol；HDL-C)、血糖、肝腎功能、甲狀腺功能、電解質及尿液等。結果顯示，在食用產品 8週後，試驗組有顯著調降血脂效果，總膽固醇和LDL-C分別顯著下降 25.45 mg/dl(11.1%) 和31.44 mg/dl(20.5%)，試驗證實山藥紅麴能有效調降血脂。

關鍵字

山藥紅麴 ； 膽固醇 ； 低密度脂蛋白膽固醇

並列摘要

According to World Health Organization statistics in 2014, the top cause of death is ischemic heart disease. Heart disease is closely associated with atherosclerosis and hyperlipidemia. Lowering cholesterol can effectively reduce the incidence of symptoms of hyperlipidemia. Red mold rice (RMR) is a common health food for lowing serum cholesterol in Eastern Asia. NTU568, is a red mold rice product which is fermented with dioscorea, is called red mold dioscorea (RMD). This clinical trial is to evaluate hyperlipidemia by using RMD, 40 subjects were enrolled and divided into two groups (experimental group and placebo group). The criteria were total cholesterol over 180 mg/dl and triglyceride between 130-190 mg/dl, who were not taking lipid-lowering drugs (20 to 65 years old). Each subject took one capsule of RMD or placebo every day (0.5 g capsule) after the meal every day. The study has 2 weeks of run in period, 8 weeks of intervention period, and 4 weeks of follow-up period. At the week of 0, 2, 6, 10, 14, blood was collected and the status was recorded. Anthropometric measurements (body weight, body fat, blood pressure) and biochemical parameters, including triglyceride, total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), blood glucose, liver and kidney function, thyroid function, electrolytes, and urine were determined. Results showed that the experimental group had significant effect on lowering- cholesterol, Plasma cholesterol and LDL-C were significantly decreased 25.45 mg / dl (11.1%) and 31.44 mg / dl (20.5%) after 8 weeks of administration. This study confirmed that RMD showed positive effect on the regulation of blood lipids.

並列關鍵字

red mold dioscorea ； total cholesterol ； LDL-C

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