山藥紅麴降低血糖之功效

在我國， 2013年死於糖尿病的人口有9,438人，居十大死因的第4位。血糖控制不良會導致大血管、小血管及神經病變。因此如何控制血糖是現今保健的重要議題。過去的動物研究顯現紅麴可有效調控血糖並降低糖尿病引起之併發症。本研究擬以人體臨床試驗，探討補充山藥紅麴對於血糖控制不良族群改善血糖調節的情形並了解其作用機制。人體試驗納入條件為空腹血糖值在100-180 mg/dl且糖化血色素小於9%者，經醫師判定仍不需使用糖尿病用藥。納入符合條件共40人，採隨機雙盲平行試驗，分為安慰劑組(n=20)與試驗組(n=20)，依組別每日提供2顆安慰劑膠囊(澱粉)或山藥紅麴膠囊(0.5g/顆)，為期12週，停止食用後4週為追蹤期。在第0、6、12、16週紀錄體位變化與血壓，並收集血液及尿液，測定空腹血糖、葡萄糖耐受性、胰島素、胰島素抗性、血脂、肝功能、腎功能、甲狀腺功能等生化指標。結果發現，試驗組在12週介入後空腹血糖有顯著下降，葡萄糖耐受性沒有顯著變化，但4位葡萄糖耐受不良者，有顯著改善。為進一步了解山藥紅麴調降血糖之作用機制，使用肌肉細胞C2C12細胞株，探討山藥紅麴之作用。結果發現山藥紅麴可以顯著提升C2C12肌肉細胞對葡萄糖的攝入。由本研究可知，食用山藥紅麴具有調節血糖之功能。

關鍵字

山藥紅麴；空腹血糖； C2C12細胞

並列摘要

9,438 people were dead due to diabetes in Taiwan in 2013. Diabetes was the 4th of the nation's top 10 causes of death. High blood glucose can lead to macrovascular disease, small vessel disease (retinopathy, kidney disease) and neuropathy. Therefore, well control blood glucose becomes an important healthy issue nowadays. Past animal studies show that the Monascus can lower blood glucose and reduce the damage caused by complications of diabetes. This study was to investigate whether the red mold dioscorea can improve the blood glucose control by a human clinical trial. This human clinical trial included 40 subjects with fasting blood glucose level between 100-180 mg / dl and glycated hemoglobin (HbA1c) < 9%, and diagnosed without medication by doctor. This study was a randomized, double-blind trial. All subjects were randomized into placebo (n= 20) and experimental group (n= 20). Each subject took two placebo capsules (starch) or red mold dioscorea capsules every day for continuous 12 weeks. Four weeks after stop using the sample or placebo were follow-up period. Blood and urine were collected at the initial, 6th, 12th, and 16th week. The anthropometric indicators, blood pressure, fasting plasma glucose level, postprandial plasma glucose (PC) level, insulin level, insulin resistance, blood lipid changes and liver, kidney, thyroid function index were measured. Results showed that fasting glucose levels in experimental group were significantly reduced after 6 more weeks of administration. No significant change were found in postprandial blood glucose (PC), but 4 subjects with poor glucose tolerance were greatly improved. To understand the blood glucose regulation, C2C12 muscle cell pretreated with or without 150 nM insulin was used to evaluate the effect of red mold dioscorea on glucose uptake. Results showed that red mold dioscorea could increase glucose uptake significantly. In conclusion, red mold dioscorea can help to regulate the blood glucose.

並列關鍵字

red mold dioscorea ； fasting plasma glucose ； C2C12 cells

參考文獻

Association, American Diabetes. "Diagnosis and classification of diabetes mellitus. " Diabetes Care 33, no. Supplement 1 (2010): S62-S69.

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Chen, Chien-Li and Tzu-Ming Pan. "Red Mold Dioscorea: A potentially safe traditional function food for the treatment of hyperlipidemia. " Food Chemistry 134, no. 2 (2012): 1074-1080.

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山藥紅麴降低血糖之功效

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