添加鍶對於鈣矽骨替代物的物理化學性質及生物相容性之影響

鈣矽骨水泥被視為是一個具有潛力的生醫骨填補物，而鍶是人體內的一個微量元素，常被用於治療骨質疏鬆症，主要是因為鍶能誘導成骨細胞活性，刺激骨生成，並且能夠抑制噬骨細胞減少骨吸收，故在本研究中，主要是評估添加鍶之鈣矽骨水泥其物理化學性質以及生物相容性。利用sol-gel的方式來製備含鍶之鈣矽粉體，鍶含量為鍶鈣的莫爾比Sr/(Sr+Ca) ，含量分別為0%、1%、5%以及10%。主要分析方式有晶相分析（XRD）、微結構分析（SEM）、對徑拉伸強度測試（DTS）及硬化時間測試（setting time）。在結果方面，各組的粉體顆粒大小約在1-5μm。在XRD結果可以觀察到粉體的結晶相在繞射峰2θ = 32°到34°之間，其峰值明顯較大，推測是由於β-Ca2SiO4相，在藉由離子交換後，部分的鈣被鍶所取代，且由於鍶的離子半徑（1.13Å）比鈣（1.00Å）大，在鍶併入鈣矽陶瓷中之後，可能導致峰值的變寬。在混合水之後，可以觀察到結晶相的繞射峰2θ = 29.3°有鈣矽水合（calcium silicate hydrate）的峰值。硬化時間方面，添加10%鍶的硬化時間也從控制組的22分鐘減少到了17分鐘。至於強度結果則並沒有明顯的改變，範圍在2.0~2.4 MPa。因此，包含鍶的鈣矽骨水泥有可能是具有潛力的鈣矽骨填補物。

關鍵字

骨水泥

並列摘要

Calcium silicate cements (CSC) have been regarded as a potential biomaterial for bone graft substitutes. Strontium (Sr) is a trace element in human body and been used for treatment of osteoporosis. Sr is found to induce osteoblast activity by stimulating bone formation and to reduce bone resorption by restraining osteoclasts. The aim of this study was to evaluate the physicochemical properties of Sr-containing CSC. The calcium silicate with equimolar ratio of Ca to Si was used as the control. Various amounts of Sr with a molar ratio of 1%, 5% and 10% for Sr/(Sr + Ca) were added to sol-gel precursors. The major techniques used for characterizing the various specimens included X-ray diffraction (XRD), scanning electron microscopy (SEM), diametral tensile strength and setting time. As a result, the particle size of calcium silicate ceramics powder ranged from 1 μm to 5 μm. The XRD patterns shows that major diffraction peaks of the four powders were at 2θ between 32 and 34o attributed to β-dicalcium silicate (β-Ca2SiO4) phase. Although the Ca was replaced in part by Sr through ionic exchange, the incorporation of Sr to calcium silicate ceramics may lead to a broadening peak. This can be explained by the fact that the radius of Sr ions (1.13Å) is larger than that of Ca ions (1.00Å), namely, the microstrain effect. After mixing with water, XRD patterns of all cements revealed an obvious diffraction peak around 2θ = 29.3o, corresponding to the calcium silicate hydrate gel, and incompletely reacted inorganic component phases of β-Ca2SiO4. 10% Sr significantly shortened setting time from 22 min for the CSC control to 17 min. The addition of Sr did not affect the strength ranged from 2.0 to 2.4 MPa as these specimens were not significantly different (p > 0.05) from control groups (2.5 MPa). Our findings indicated that Sr-CSC may be a candidate for bone repair.

並列關鍵字

bone cement

參考文獻

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添加鍶對於鈣矽骨替代物的物理化學性質及生物相容性之影響

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