牙周病第一階段治療配合使用含三氯生/共聚合物牙膏之臨床研究

The clinical trial of the phase I periodontal therapy combined with triclosan/copolymer dentifrice

林榮德(Jung-Te Lin)

指導教授 ： 楊麗秋

中山醫學大學/口腔醫學院/牙醫學系碩士班/碩士(2009年)

https://doi.org/10.6834/CSMU.2009.00128

摘要

牙周病，是目前全世界最普遍的口腔疾病之一，根據調查國人的罹患率也高達9成以上。牙周致病菌是牙周病的主要因素，會導致牙齒周圍組織發炎，並使牙周黏附組織及支持骨頭喪失，進而造成牙齦退縮與牙齒動搖，造成美觀或是功能上的障礙，所以如何控制及治療牙周疾病是相當重要的。治療牙周病的初期需要完整牙齦上下牙結石清理及牙根整平術，在過程中控制牙周致病菌是成功預後的關鍵之一。含三氯生/共聚合物(Triclosan/copolymer)成分的牙膏具有廣效性抗菌能力，可長時間貼附且作用於牙齒表面，達到抗菌及抑制發炎的效果。本論文針對已罹患全口嚴重慢性牙周病的成年自願者，以隨機分派為實驗組與控制組，進行牙周病第一階段治療到第二次牙周囊袋測量的過程中，實驗組搭配使用含三氯生/共聚合物成分的牙膏，控制組使用傳統含氟牙膏，觀察其在牙周病嚴重程度(牙周囊袋深度及牙周黏附喪失)，牙周發炎程度(探測時流血)，及口腔衛生維護指數(全口牙菌斑指數)的表現 比較前後差異。並以原始牙周囊袋分類為淺囊袋，中度囊袋，深囊袋來比較兩組改善程度的差異。結果顯示在牙周病第一階段的治療過程中，實驗組牙周發炎程度及口腔衛生維護的程度較控制組有明顯改善。

關鍵字

牙周病 ； 三氯生/共聚合物 ； 第一階段治療 ； 非手術性牙周治療

並列摘要

There are a lot of people suffering from the damage caused by periodontal diseases throughout the world. In Taiwan, patient having periodontal problem is more than 90% of the population. As the result, the method to control and treat periodontitis is rather important. In the primary stage of treating periodontitis, integrated supragingival and infragingival scaling and root planning is required. In the process, controlling the bacteria which induced periodontitis is also one of the key elements for successful prognosis. Triclosan/Copolymer are toothpaste (dentrice) containing broad-antibacterial component. Their anti-bacterial and inflammation-inhibiting function can attach and effect on the surface of the teeth for a long period of time. In our study, volunteers with severe generalized chronic periodontitis are randomly divided into two groups. The experiment group was given Triclosan/Copolymer-containing toothpaste, whereas the control group was given only fluoride-containing toothpaste without antibacterial ingredients. We had the patient under test for clinical periodontal inflammation index, including pocket depth (PD), clinical attachment loss (CAL), bleeding on probing (BOP), full mouth plaque score (FMPS), then asked patients use given toothpaste twice a day during the phase I periodontal treatment. After six weeks, we did the second measurement. We also analyzed periodontal improvement according to the primary periodontal pocket classification, whether the depth is (1)PD≦4mm (shallow pocket) (ii)4mm＜PD≦6mm (moderate pocket) (iii) PD＞6mm (deep pocket), but the experiment and control group have no statistical difference. In conclusion, the result in our study indicated using the Triclosan/Copolymer-containing toothpaste have significant improvement on inflammation management and plaque reduction when compare with standard fluoride containing toothpaste.

並列關鍵字

Periodontitis ； Triclosan/Copolymer toothpaste ； Phase I treatment ； Non-surgical periodontal treatment

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