直鏈脂肪酸對聚己內酯/氫氧基磷灰石 奈米複合膜材的表面性質與生物活性的影響

Effects of straight-chain fatty acids on the polycaprolactone / hydroxyapatite composite nano-membrane surface properties and bioactivity

白玉林(Yu-Lin Pai)

指導教授 ： 湯正明

中山醫學大學/口腔醫學院/口腔生物暨材料科學研究所/碩士(2011年)

https://doi.org/10.6834/CSMU.2011.00163

摘要

氫氧基磷灰石(HA)/聚己內酯(PCL)複合材料近年來廣泛應用於硬骨修
復。當疏水性的高分子與親水性陶瓷混合時，材料內部易產生相分離的現
象而降低機械強度。本研究以直鏈性脂肪酸作為界面活性劑，以提高陶瓷
在高分子基質中的分散性，並增加材料的生物活性。本研究使用的陶瓷粉
體包含氫氧基磷灰石粉體(HAnon)與含有5%硫酸鈣的氫氧基磷灰石粉體
(CS5non)，而經燒結程序後的粉體分別命名為Has20 與CS5s20。本研究添
加脂肪酸[正己酸(C6)、月桂酸(C12)、油酸(C18)、魚油(FA)]進入高分子溶
液裡，提高陶瓷粉末在膠體溶液裡的穩定性，高分子溶液鑄膜後進行SEM、
ATR-FTIR、XRD 以觀察其表面的特性。並將膜材置入模擬體液(SBF)中浸
泡七天後，取出後進行SEM、ATR-FTIR、XRD 以觀察其表面的特性。結
果顯示指出以脂肪酸調解之複合材料中相分離現象明顯降低，而以模擬體
液浸泡實驗證實其生物活性也有良好的效果，本研究期望未來能應用於組
織引導再生膜或硬骨骨膜取代物方向繼續發展。

關鍵字

氫氧基磷灰石 ； 聚己內酯 ； 脂肪酸 ； 界面活性劑 ； 人體模擬體液 ； 磷酸鹽緩衝液

並列摘要

In recent years, Hydroxyapatite (HA) / polycaprolactone (PCL) composite
materials are widely used, such as the repair of hard bone defect. When the
hydrophobic polymer and hydrophilic ceramic was blend, the material inside is
easy to produce phase separation, then mechanical strength is reduced. In our
study, straight-chain fatty acids as surfactants, to improve the ceramic were
dispersed in the polymer matrix of the dispersion, and increased biological
activity of the material. The kinds of Ceramic powders was used, include
Hydroxyapatite powder (HAnon) and 5% calcium sulfate in hydroxyapatite
(CS5non), and CS5s20 named HAs20 was obtained by the powder sintering
procedure. fatty acids was added into polymer solution, included hexyl acid
(C6), lauric acid (C12), oleic acid (C18), fish oil (FA). Therefore, colloidal
stability of ceramic was increase in polymer solution. Then composite
membrane was produced by solvent casting. The surface characteristics were
observed by SEM, ATR-FTIR, XRD. The bioactivity of membrane was
evaluated by the membrane immersied the simulated body fluid (SBF) after
seven days. The results showed that phase separation of composite
significantly reduced by the fatty acid mediation.

並列關鍵字

Hydroxyapatite ； Polycaprolactone ； Fatty acids ； Surfactant ； Simulated body fluid ； Phosphate buffer solution

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