US patent litigation has always been the main battlefield for international patent litigation. After the implementation of the American Inventions Act (AIA) in 2011, the Inter Partes Review(IPR) has become a common procedure for defendants in patent infringement litigation. Because IPR has both judicial and administrative characteristics, and is governed by the United States Patent Trial and Appeals Board (PTAB), it forms a dual-track system for determining the validity of patents with the patent invalidation process in patent litigation in the Federal Court. Because the procedures of the two systems are different in terms of schedules and regulations, there will be interactions between them. There are also estoppel regulations on the subject and the object, causing some conflicts and competition. This thesis uses comparative analysis of laws and regulations and collected relevant case explanations to explain the application of relevant laws and regulations in practical judgments, and finally provides suggestions on litigation strategies for the parties.