近幾年來,由於生物晶片的快速發展,其微總體分析系統(Micro Total Analysis System)便是將生醫檢測上取樣、樣本傳輸、混合、分離及偵測等功能,故流體分離與流體閥門設計為生物晶片設計之基礎且重要之設計,亦為本論文之重點。 本論文考慮離心力與科氏力之影響,且提出行星式碟片閥門模式(Planetary LabCD Valve Model)與單點流體分離閥門模式(SPFS Valve Model)兩模式,其中行星式碟片閥門模式,其臨界轉速與行星角之大小近於線性變化,可當於控制閥門之臨界轉速之設計參數,且比較在閥門設計上考慮行星角來控制閥門臨界轉速與James Lee之閥門臨界轉速理論(無考慮行星角)可以得知,從吾人所提出行星式碟片閥門模式可以得到與實驗結果相同的趨勢。其單點流體分離閥門模式中定義γR(體積分離比值)其值顯示與臨界轉速在低轉速下成線性關係,在高轉速之飽和區中不論何種轉速皆近於定值,而與實驗結果相當符合。由此兩種閥門設計,吾人發展一AutoLisp之AutoCAD分析軟體,使得微流體生物光碟片閥門之設計與實驗可以快速得到理論與實驗結果而實現閥門轉速控制與分離功能。
Due to the fast develop of Biochip recently μTAS ( Micro Total Analysis System ) minimize and integrate analytical instrument into biochip which includes sampling, sample transport, reaction, separation and detection function is most promising. So the fluid separation and valve design are not only the foundation and major design for LabCD but also the important point in this paper. This paper consider centrifugal force and coriolis force for ideas of Planetary LabCD Valve Model and Single Point Fluid Separation Model, then the relation of critical rotation speed and planetary angle is linear which control parameter of critical rotation speeding in the Planetary LabCD Valve Model and compare with James Lee theory, and define γR (volume separation ratio) in SPFS Valve Model to show the relation of the low rotation speed is linear and is fixed where the high rotation speed for utilizes any rotation speed. So we develop a software of AutoLisp in AutoCAD for design LAbCD valve in our experiment.