磁性氫氧基磷灰石之製備分析及作為癌症熱療之研究

The Fabrication and Characterization of Magnetic Hydroxyapatite as Thermoseed for Cancer Hyperthermia

王慶文(Chin-Wen Wang)

指導教授 ： 許淙慶 ； 林峰輝

國立臺北科技大學/工程學院/材料科學與工程研究所/碩士(2007年)

摘要

鐵和鋅在人體細胞功能是相當重要的元素，高濃度的鐵、鋅分布在人體之血液、肌肉以及循環系統。在癌症治療方面，溫熱療法是目前熱門的研究方向，結合鐵、鋅與氫氧基磷灰石形成帶有磁性之化合物，利用此磁性可使此種氫氧基磷灰石具有應用在腫瘤熱治療上之潛力。
本研究利用共沉法合成氫氧基磷灰石，過程中分別添加不同濃度的氯化鋅以及氯化亞鐵以改變原來氫氧基磷灰石的原子組成，反應過程中溶液維持在pH = 9 ~ 9.5、溫度80℃下進行，合成出的粉末以磁滯曲線分析其磁性質。當進一步提供交流電感應磁場時，材料因磁滯損失而產生熱能，使得材料的溫度上升，且經由生物測試過後，發現其具有好的生物相容性，則此材料未來可能應用在溫熱療法的治療上。

關鍵字

溫熱療法 ； 共沉法 ； 氫氧基磷灰石 ； 交流電感應磁場 ； 磁滯損失

並列摘要

In human body and cells, iron and zinc are very vital elements. High concentration of iron and zinc ions are distributed over the blood, muscle, and the circulatory system. Iron-based and zinc-based compounds can combine with hydroxyapatite and form composites which can presents magnetism. This kind of iron-zinc-containing hydroxyapatite have the potential in Tumor Hyperthermia Application which is the most popular subject in research.
In this research, we use the co-precipitation method to synthesize hydroxyapatite. Adding zinc chloride and ferrous chloride with different concentration can modify its atomic structure. Powder composites are prepared at pH = 9 ~ 9.5 and temperature at 80, and then ℃we can obtain its magnetic properties with hysteresis curve analysis. In this study, when we impose a AC - induction magnetic field on our samples, their temperature rise because of hysteresis loss. With In-vitro test, we know that it also has good bio-compatibility and high potential for Tumor Hyperthermia in the future.

並列關鍵字

magnetism ； hysteresis curve ； co-precipitation method ； bio-compatibility

參考文獻

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