硫酸鈣與磷酸鈣複合之研究

人體骨骼主要的成分為鈣與磷，所以我們所使用的骨替代材為硫酸鈣及磷酸鈣，此兩種材料都具有良好的生物相容性。此種骨替代材的特性為植入人體骨缺損處後，鈣離子（Ca2+）會被人體所吸收且誘導新骨由此處形成，良好的骨替代材必須在人體內使骨誘導性及骨吸收性達成一種動態平衡。而本實驗以硫酸鈣（CSD）為主，分別添加入二水磷酸鈣（DCPD）、磷酸三鈣（TCP）、氫氧基磷灰石（HA）以形成複合骨替代材。由於硫酸鈣具有良好的機械強度，置於人體內可以代替骨骼的支撐能力，所以用硫酸鈣做為我們試片的主要成分；為了讓鍵結力較強的硫酸鈣較慢被人體所吸收，所以我們添加了鍵結力較弱的磷酸鈣使其先被人體所吸收，使得孔洞產生及釋放出鈣離子，以達到骨誘導性的功能。本實驗的重點著重於不同磷酸鈣之骨替代材的機械強度、孔隙率、降解速率的變化，且由SEM圖及XRD繞射解釋含有不同磷酸鈣之變化情形，接著做生物相容性（In Vitro試驗）實驗，如此才能選出優良的骨替代材。

關鍵字

硫酸鈣；二水磷酸鈣；磷酸三鈣；氫氧基磷灰石

並列摘要

The main ingredients of the human skeleton of calcium and phosphorus, so we use bone substitute materials for calcium sulfate and calcium phosphate, both materials have good biocompatibility. Such bone substitute material characteristics for the implantation of human bone defect, calcium ion （Ca 2 + ）will be absorbed by the body and induce new bone formation by here, a good bone substitute material in the human body to bone induction and bone resorption to achieve a dynamic equilibrium. In this experiment, the calcium sulfate （CSD） were added into the dihydrate calcium phosphate （DCPD）, tricalcium phosphate （TCP）, hydroxyapatite （HAP） to form a composite bone substitute material. Because CSD has a good mechanical strength, placed in the human body can replace bone support, so the main ingredient for our specimens with CSD; strong bonding force calcium sulfate was absorbed slowly by the body. Therefore, we add a weak bonding calcium phosphate to first by the human body absorption, making holes in the generation and release of calcium ions, in order to achieve the function of bone induction. The experiment focuses on the different calcium phosphate bone substitute material mechanical strength, porosity, degradation rate changes, and explain the change of situation with different calcium phosphate by the SEM and XRD, and then do the biocompatibility （In Vitro test） experiment, in order to select a good bone substitute material.

並列關鍵字

Calcium sulfate ； Dihydrate calcium phosphate ； Tricalcium phosphate ； Hydroxyapatite

參考文獻

[1] Mirtch, A. A., Lemaitre, J., “Bone repair of defects filled with a phosphocalcic hydraulic cement:an in vivo study,” J. Mater. Sci. in medicine, Vol. 4, 1993, pp. 337-344.

[3] Price N., Bendall S. P., Frondoza C., Jinnah R. H., David S. H., “Human osteoblat-like cells （MG63） proliferate on a bioactive glass surface,” John Wiley & Sons, Inc., Vol. 37, 1997, pp. 394-400.

[4] Gomez-Vega J. M. , Saiz E. , Tomsia A. P. , Marshall G. W. and Marshall S. J. , “Bioactive glass coatings with hydroxyapatite and Bioglass particles on Ti-based implants. 1. Processing,“ Biomaterials, Vol. 21, 2000, pp. 105-111

[5] Gomez-Vega J. M. , Saiz E. , Tomsia A. P. , Marshall G. W. and Marshall S. J. , “Bioactive glass coatings with hydroxyapatite and Bioglass particles on Ti-based implants. 1. Processing,“ Biomaterials, Vol. 21, 2000, pp. 105-111

[6] Coetzee A. S., “Regeneration of bone in the presence of calcium sulfate,” Arch Otolaryngol Vol. 106, 1980, pp. 405-410.

國際替代計量

硫酸鈣與磷酸鈣複合之研究

全文下載

主題瀏覽