- 學位論文
葉酸接枝之檸檬酸銨鐵作為腫瘤熱治療之研究
Folic acid conjugated ammonium ferric citrate for cancer hyperthermia
並列摘要
The malignant neoplasm is a worldwide disease and has been ranked in the leading causes of the death for Taiwan people in 2006. There are many different methods of cancer treatments, such as surgery, chemotherapy, radiation therapy, and direct heat hyperthermia, but the effectiveness of these therapies is limited by the complications of cancer. Magnetic induction hyperthermia can apply heat to cancers at the deep region in a living body and overcomes some disadvantages of conventional cancer treatments. Ammonium ferric citrate exhibits biological activities and are used as a contrast agent for magnetic resonance imaging due to its magnetic property. Folic acid is a high affinity ligand of the folate receptor which is absent in most normal tissues and overexpressed on various types of tumors. Therefore, folic acid conjugated ammonium ferric citrate administered intravenously is supposed to be taken by cells via receptor –mediated endocytosis. In this study, folic acid conjugated ammonium ferric citrate was prepared by carbodiimides cross-link agent. Targeting AFC was characterized by FTIR, NMR, VSM, and AA analysis. Cytotoxicity and proliferation of materials to cells were evaluated by crystal violet, LDH, and WST-1 biological assay kits.
參考文獻
延伸閱讀
- 蔡亞霖（2014）。葉酸標靶遞送抗拓樸酶奈米化藥物在腫瘤細胞之療效分析〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2014.10352
- 林嫈梓（2007）。具葉酸標的功能之多醣體作為抗癌藥物載體之製備及分析〔碩士論文，高雄醫學大學〕。華藝線上圖書館。https://doi.org/10.6832/KMU.2007.00106
- Chen, C. C., Chen, H. C., Chung, C. Y., Chang, T. H., You, J. J., Huang, T. M., & Lin, T. C. (2008). 每週一次注射低劑量5FU及葉酸為第三期大腸直腸癌患者輔助化學治療的長期追踪報告. 中華民國大腸直腸外科醫學會雜誌, 19(1), 1-8. https://doi.org/10.6312/SCRSTW.2008.19(1).09620
- 黃依柔（2009）。Study the effect of vitamin B12 and folic acid to Pemetrexed (Alimta) efficacy with human lung cancer cells〔碩士論文，中山醫學大學〕。華藝線上圖書館。https://doi.org/10.6834/CSMU.2009.00010
- 吳駿麟（2022）。Utilization of lactic acid bacteria to produce natural folate〔碩士論文，國立屏東科技大學〕。華藝線上圖書館。https://doi.org/10.6346/NPUST202200359