- 學位論文
探討臨床關節液之組成成份及其與人工關節材料摩擦行為之相關性
To Investigate the Composition of Clinical Synovial Fluid and the Effect on the Tribological Performance of Artificial Joint Materials
摘要
現今人工關節植入物所使用的材料主要為鈷鉻鉬合金（Co-Cr-Mo）以及超高分子量聚乙烯（ultra-high molecular weight polyethylene, UHMWPE）。對於由軟骨形成的正常人體關節介面而言，人工關節材料間相互對磨之介面，關節潤滑液分子會形成一層極薄的薄膜來提供潤滑。但人工關節互相對磨材料介面間的磨耗，遠大於正常的人體關節。如何減低人工關節對磨材料間的磨耗，以延長人工關節的使用年限，一直是骨科醫師及相關研究人員努力的目標。 關節潤滑液可覆蓋於人工關節表面，並形成足以抵抗關節間磨耗的保護膜。其主要成分包括白蛋白（albumin）、球蛋白（IgG）、玻尿酸（HA）、磷脂質（phospholipid）等，可想而知，不同成分比例的潤滑液會有不同的摩擦特性，相對地，也會影響形成的潤滑薄膜所表現出的物理化學特性。本研究將取得的臨床關節液檢體，定量其各種組成，且測量其摩擦係數與黏度，並利用統計加以分析來評估這些成分對於摩擦行為的影響。結果指出，在兩種不同群組病患中，其磷脂質含量與摩擦係數呈皆負相關，表示在整體趨勢上摩擦係數隨著磷脂質濃度的增加而減少；而玻尿酸含量與摩擦係數間則無明顯相關。
並列摘要
At present, joint prosthesis is mainly composed of cobalt-chromium-molybdenum (CoCrMo) and ultra-high molecular weight polyethylene (UHMWPE). When compared to the articulation of articular cartilages, the artificial joint undergoes a boundary lubrication in which a thin layer of synovial fluid molecules was formed between the artificial joint materials. Therefore, a larger wear rate was observed in the artificial joint system. Various compositions such as albumin, globulin, hyaluronic acid and phospholipid are contained in the synovial fluid. Therefore, the lubrication thin film properties from various compositions are critical to the tribological properties of artificial joint materials. In this study, we are going to retrieve the synovial fluids for quantitative analysis of various compositions. The friction coefficients and viscosity of the collected synovial fluids will be measured as well. Than, we are able to estimate the effect of synovial fluid biomolecules on the tribological performance of artificial joint. The results obtained from the retrieved synovial fluid indicate the same trend. The correlation between the concentration of phospholipid and the friction coefficient was significant. However, it can also be observed that the correlation between concentrations of hyalurohic acid and the friction coefficient was not significant.