糖尿病藥物併發腎病變之研究

The Study of Diabetic Related Nephropathy Complications Devived from Diabete Prescriptions

黃明哲(Ming-Zer Huang)

指導教授 ： 趙豫州

國立臺北科技大學/工程學院/有機高分子研究所/碩士(2005年)

摘要

糖尿病為一種複雜的慢性代謝性疾病，若失控制不良，將導致神經病變(neuropathy)、視網膜病變(retinopathy)、腎病變(nephropathy)、心血管疾病(cardiovascular disease)等併發症的出現，甚而造成殘障，或導致死亡，對個人、家庭、社會乃至於國家，都是相當大的損失與負擔。因此，在國內人口結構趨向於高齡化之際，糖尿病的最佳治療模式是一個值得探討的課題。本研究以國家衛生研究院的健保資料基礎，特經過歸人處理擷取五年內曾經發生腎衰竭(Renal Failure)、血液透析(Hemodialysis, HD)、腹膜透析(Peritoneal, PD) 及腎臟移植(Kidney Transplant)之糖尿病患者的資料，依其糖尿病用藥的三種方式：口服單一糖尿病用藥、單獨注射胰島素或併用口服糖尿病用藥以及口服兩種以上糖尿病用藥，交叉比對分析併發腎病變之發生率，並比較腎病變之醫療費用。透過專業之統計分析軟體(Statisitcal Analysis System (SAS) 8.1)交叉比對分析、合併回溯性分析以及運用電腦模組處理等多重技巧，進行找出最適糖尿病用藥處方之治療模式。

關鍵字

糖尿病 ； 腎病變 ； 血液透析 ； 腹膜透析 ； 腎臟移植 ； 腎衰竭

並列摘要

The diabetic is a complicated metabolism disease. If it is controless, it will cause neuropath, retinopathy, nephropathy, and cardiovascular disease. Then cause to die. It is a large cost and burden. Therefore, population structure tend to ripe old age in Taiwan, the better prescription models in diabetic care are expected. The raw material of this study is based on the 5 years database from National Health Research Institute. After data mining and statistic analysis for patients with the history of renal failure, hemodialysis, peritoneal dialysis and kidney transplant. Major groups for prescription behaviors are divided into mono-therapy by (a) oral anti-diabetics, (b) combination therapy by insulin pluses oral anti-diabetics, and (c) combination therapy by more than one oral anti-diabetic without insulin. To compare the cost, cure effect and complication for diabetic. Intersective analysis and combine recall analysis by Statistical Analysis System (SAS) 8.1 and hope to provide the better prescription models.

並列關鍵字

Diabetic ； Nephropathy ； Hemodialysis ； Peritoneal dialysis ； Kidney transplant ； Renal failure

參考文獻

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