- 學位論文
生技製藥廠之負壓實驗室氣流模擬
Design and Airflow Simulation of Negative Pressure Pharmaceutical Laboratory
摘要
現代趨勢潮流對生命科學益發重視之際，生技產業迅速蓬勃發展，而生化實驗室為製藥品管，生技研發所必需的環境。生技環境的實驗室為防制生物級危害多採用負壓實驗室，必須於設計階段考量安全性(正確的氣流向、相對室內壓差)、舒適可靠的環控條件(溫濕度、潔淨度)。本研究即規劃負壓實驗室以電腦模擬軟體FLUENT 計算流場，包括壓力場、速度場、溫度場、粒徑流場，評估當負壓實驗室改變參數，如進風口位置、出風口位置數量、送風量、壓差改變與操作條件改變，研究比較相互間的氣流狀態，分析優缺點，以希冀得到優化之設計。本研究的模型設置其氣流模擬，分析結果為洩漏風量對室內流場有相當影響；壓差越大，洩漏風量越大，在室內的氣流擾動現象更嚴重。實驗室設備布置，空隙處會產生渦流及回流。排氣口布置上排氣較下排氣可得到較均勻的溫度性，適當的增加送風量有助於層流穩定及排汙功能，而後側增加排氣口有抑制回流的優點，側壁送風式在本研究模型中有較好的氣流模式。
並列摘要
The purpose of this As modern trend places more emphasis on life science, the biotechnology industry develops vigorously and quickly. Biochemistry lab is an essential environment for pharmaceutical quality control and biotechnology R&D. In most cases, a biotechnical laboratory adopts negative pressure to prevent biological hazard, safety (e.g. correct air flow direction, indoor pressure difference), comfortable and reliable environment control conditions (e.g. temperature, humidity, cleanliness) must be taken into consideration in design process. This study designed a negative pressure laboratory by using simulation software FLUENT to compute fluid fields, including pressure field, velocity field, temperature field, particle flow field. It also evaluated parameter change of negative pressure laboratory, such as air inlet location, air outlet location/numbers, air output, pressure difference and operation condition change. This study then examined and compared air flow state, analyzed advantages and disadvantages, in order to get optimum design. A gas flow simulation was conducted, and the results showed that air leakage had great impact on indoor flow field. At greater pressure difference, the air leakage was higher, and indoor gas flow disturbance was more serious. In lab equipment layout, there was vortex flow and backflow at the space. In terms of air exhaust, upward exhaust could lead to more even temperature than downward exhaust, and a proper increase of air output would enhance the laminar flow stability and sweat-discharging function. An addition of air exhaust at the rear side was advantageous in suppressing backflow.