- 學位論文
中孔洞生醫玻璃之合成及性質探討
Synthesis of mesoporous bioglass and the characteristics study
摘要
生醫玻璃(bioglass)屬於生物活性陶瓷的一種，過去研究指出生醫玻璃於體外(in vitro)研究上，成份與組織結構有一定的相依性，其原因在於生醫玻璃在動物組織間的反應程度，是屬於第三大類的表面活性生醫陶瓷。為了使生醫玻璃能夠與動物周圍組織間直接建立良好的化學鍵結，必須在生醫玻璃材料表面上沉積出與動物骨骼組織間相似的氫氧基磷灰石相。因此，除了材料的成份外，結構的性質也影響了形成氫氧基磷灰石的生成速率及方式。所以本研究的目的是利用三區塊共聚高分子界面活性劑(P123)為生成模板，經由溶膠-凝膠法以及熱處理方式合成出具規則性排列之奈米中孔洞(meso-pore)生醫玻璃材料，其中實驗分有四個部份去探討，有界面活性劑與無機前趨物的含量改變對於形成孔洞的因素影響，再來溫度的作用下端看其孔洞規則性的現象，最後的環境溫度變化能否控制孔洞的尺寸狀態，都是本實驗最期待的部份。 實驗結果顯示，以三區塊共聚高分子作為天然模板，於室溫環境合成下經煆燒後可產出奈米中孔洞生醫玻璃材料，藉由恆溫吸/脫附儀的量測並配合BET與BJH的理論，顯示所具有的中孔洞平均孔洞尺寸大小在2.9~4.1 nm之間，而由吸/脫附圖型曲線的趨勢走向，可以知道本研究所製備的生醫玻璃內部的有序中孔洞為圓柱狀通道的孔洞型態，而BET比表面積值最大值在320.15 m2/g。由X光小角度繞射(Small-angle XRD)發現在2θ=1.1o左右會出現強烈的繞射峰值，亦即表示試片內部具有有序排列的中孔洞結構。此外，其他的結果，如界面活性劑添加量的多寡，可清楚顯示微胞堆積的情況會影響中孔洞材料的結構。當溫度效應可以使散亂的孔洞支架增加其規則度，是利用小角度繞射圖與穿透式電子顯微鏡影像圖分析後的結果中，可清楚得知溫度確實是具有很強的控制孔洞排列能力。添加量比例過多的三乙基磷酸鹽(TEP)成份、四水硝酸鈣(Ca(NO3)2
並列摘要
The bioglass is a kind of bioactive ceramic, in the past studies, the in vitro test shown that the tissue structure was dependent to the composition of bioglass. In order to improve the chemical fixation between the bioglass implant and the bone tissue, the precipitation of hydroxyapatite coating on the implant surface was needed. Moreover, beside the composition of bioglass, the structure of bioglass was also an important factor to affect the deposition rate and performance of the hydroxyapatite coating. Therefore, the purpose of this study was tried to fabricate the bioglass with ordered mesoporous structure. The three block copolymer surfactant (P123) was employed as the structure agents for synthesizing the mesopore in bioglasses through the sol-gel method. The experimental result shown as the small angle x-ray diffraction shown the obvious diffraction peak in about 2θ=1.1o, it means that the high order mesoporous structure is existed in the bioglass. In addition, by measuring the isothermal nitrogen adsorption-desorption curve and the Barrett- Emmett-Teller (BET) and Barrett-Joyner-Halanda (BJH) theories, the results shown that the mesoporous structure with the pore size of 2.9~4.1 nm, the BET surface areas of 320.15 m2/g. The isothermal nitrogen adsorption- desorption curve also displayed the structure of mesopore in the bioglass was cylindrical channel type. The concentration of the surfactant(P123) is low or heavy no micelle will be formed; even micelle formation is difficult to great shape. Aging of an as-prepared precipitate at 60℃ seems to help segregation of the PEO blocks(hydrophilic) and the inorganic framework, by promoting order of mesostructure. A too many amount of ingoranic(Si(OC2H5)4, C6H15O4P, Ca(NO3)2 4H2O) network with a high rigidity due to cross-linking will be deleterious in order to obtain organization. High temperatures can change the polymer behavior, where only the hydrophobic block was related to the pore size. These results could be further confirmed by the TEM observation. The photograph reveals a highly ordered 2D-hexagonal arrangement of one-dimensional channel, it is a symmetry p6mm space group.
參考文獻
延伸閱讀
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