含抗菌媒介之生醫陶瓷複合材之細胞生長與型態

Cell proliferation and morphology of the antibacterial agent incorporated biomedical ceramic composites

江錫仁(HSI-JEN CHIANG)

指導教授 ： 黃瓊芳

臺北醫學大學/口腔醫學院/醫療器材產業碩士專班/碩士(2013年)

https://doi.org/10.6831/TMU.2013.00115

摘要

本研究將混合不同銅含量之含3 at%釔安定化氧化鋯(YSZ)複合材以燒結製程燒製成塊材進行研究。結果發現；複合材之晶粒大小明顯隨著燒結溫度增加而增大，當增加銅含量時；它會造成複合材晶格由細小之四方晶變成粗的單斜晶。Cu/YSZ複合材伴隨著細小之四方晶結構會呈現相對較高之硬度與水滴接觸角。此外，較高的燒結溫度與較多的銅含量可穩定YSZ之四方晶結構。儘管添加銅會影響材料之孔洞率與結晶結構，但它還是可降低複合材之水滴接觸角度。而於不同培育之時間點下之生物相容性比較發現；複合材與YSZ材會呈現相似之細胞貼附量。因此，這些特徵指出含奈米銅氧化鋯複合材料不會影響細胞之生長，其是屬於一個沒有細胞毒性的生物材料，並具有相當大潛力的可應用於用於牙科材料和生物醫學領域。

關鍵字

氧化鋯 ； 顯微 結構 ； 機械特性 ； 細胞毒性 ； 細胞生長

並列摘要

In this study, 3 at% Y2O3 partially stabilized zirconium (YSZ) were composited with metallic copper using sintering process. The microstructure and mechanical behavior of the Cu/YSZ composites were investigated. It was found that the grain size of composites clearly increases with the sintering temperature. When increasing the Cu content, it causes the crystal structure of composites to transform from fine tetragonal phase grain into coarse monoclinic phase grain. The Cu/YSZ composites with fine-granular tetragonal structure exhibited relatively higher hardness values and water contact angles. Moreover, high sintering temperature and overdosed Cu would damage the stabilization of tetragonal YSZ phase. Despite the effects of porosity and crystalline structure, doping Cu can lower down the water contact angle of composites. Regard to the biocompatibilities after different culturing time, the number of adhered cells on the Cu/YSZ composite ceramic is similar to that of the YSZ surface. Thus, these characteristics indicated that the antibacterial agent (Cu) incorporated zirconium oxide composite had no significantly effect on the cell growth and possess a great potential that could be applied for dental materials and biomedical fields.

並列關鍵字

Zirconium oxide ； Microstructure ； Mechanical properties ； cytotoxicity ； cell proliferation

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