多功能表面處理於植體促進骨整合研究

氟離子具有抗菌特性，被應用在牙膏上，以減少口腔內細菌滋生。鈦金屬是一種具有高疲勞強度、抗蝕性佳及優異生物相容性的金屬，因此被廣泛應用在生醫材料上，如人工植體、器械等等。有鑑於此，本研究將結合電化學表面功能性處理技術所開發之奈米多孔性二氧化鈦，並藉由氫氟酸溶液為處理液進行陽極氟化處理，更被覆著具抗菌性之氟離子。本研究分成三大部份第一部分將含氟離子之鈦試片進行物化分析與材料機械測試，探討新式電化學表面功能性處理之試片表面特性，第二部分依據ISO 10993生物相容性規範進行細胞毒性測試以及根據日本JIS Z2801:2000規範進行抗菌測試，觀察含氟離子之鈦試片之抗菌效果；第三部分安排刺激試驗、過敏性試驗以及熱原試驗等生物相容性活體動物實驗，確保材料之安全性，研究結果顯示，經表面處理後，表面產生TiH2與TiO2薄膜，並具有奈米多孔性結構，再經氟化處理後經抗菌檢測，對於金黃色葡萄球菌與大腸桿菌有高達99.9%之抗菌率，以及於活體動物之生物相容性亦符合要求。

關鍵字

氟離子,鈦植體,電化學,抗菌,骨整合

並列摘要

Fluoride ion is used in toothpaste because of its antibacterial properties, and Fluoride could decreased oral bacterial. Titanium is a high fatigue strength, good corrosion resistance and high biocompatibility metal, and also used in implant system. For this reason, we will combine the electrochemical treatment on surface to develop nano-porous Titanium oxide, and use hydrofluoric acid to anode oxidation fluoride treatment. so that the surface of titanium metal produced nanometers apart porous structure, but also with anti-bacterial coating of the fluoride ion. By the research project to explore the surface functional team developed treatment technology is able to have antibacterial properties, while maintaining excellent mechanical properties of titanium and the biocompatibility, and expect to animal effect. The first part is titanium fluoride ion specimens for mechanical testing and materials physical and chemical analysis to explore the electrochemical surface treatment of the sample surface properties, and according to ISO 10993 to test biocompatibility. The third part will arrange irritation test, delayed allergy test t and the pyrogen test animals such as biocompatibility, while according to Japanese JIS Z2801: 2000 specification for antibacterial testing, observation of fluoride ion of titanium specimens of the antibacterial effect.

並列關鍵字

fluoride ion, titanium implants, electrochemical, antibacterial, osseointegration

參考文獻

[1]T. Albrektsso, P.-I.B.N., H -A. Hansson, J.Lindstrom, Osseintegrated Titanium Implants. Acta orthop. scand., 1981. 52: p. 16.

[2]Yilmaz, H. and C. Dincer, Comparison of the bond compatibility of titanium and an NiCr alloy to dental porcelain. Journal of Dentistry, 1999. 27(3): p. 215-222.

[3]Kim, K.H. and N. Ramaswamy, Electrochemical surface modification of titanium in dentistry. Dental Materials Journal, 2009. 28(1): p. 20-36.

[4]Bobyn, J.D., et al., The optimum pore size for the fixation of porous-surfaced metal implants by the ingrowth of bone. Clin Orthop Relat Res, 1980(150): p. 263-70.

[6]Chehroudi, B., T.R. Gould, and D.M. Brunette, Titanium-coated micromachined grooves of different dimensions affect epithelial and connective-tissue cells differently in vivo. J Biomed Mater Res, 1990. 24(9): p. 1203-19.

國際替代計量

多功能表面處理於植體促進骨整合研究

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