富含難消化性麥芽糊精熟飯對第2型糖尿病大鼠醣類及脂質代謝之影響

Effects of Resistant Maltodextrin-Enriched Boiled Rice on Carbohydrate and Lipid Metabolism in Type 2 Diabetic Rats

劉淳欣(Chun-Hsin Liu)

指導教授 ： 鄭心嫻

臺北醫學大學/公共衛生暨營養學院/保健營養學研究所/碩士(2009年)

https://doi.org/10.6831/TMU.2009.00022

摘要

本研究之目的為探討富含難消化性麥芽糊精(resistant maltodextrin, RMD)熟飯對第2型糖尿病大鼠醣類及脂質代謝的影響。三十二隻雄性Wistar大鼠以streptozotocin及nicotinamide誘發成第2型糖尿病大鼠後，隨機分成RC (rice control)、33% RMD rice、67% RMD rice及100% RMD rice組。四組實驗飼料皆由AIN-93M調整，RC組由無添加難消化性麥芽糊精熟飯之澱粉完全取代玉米澱粉，33% RMD rice、67% RMD rice及100% RMD rice組則分別以33%、67%及100%富含難消化性麥芽糊精熟飯之澱粉取代玉米澱粉，共餵養四週。餵食不同實驗飼料四週後，100% RMD rice組之禁食血漿葡萄糖及胰島素濃度，顯著較RC組低 (P＜0.05)。67% RMD rice 及100% RMD rice組之胰島素抗性程度顯著低於RC組 (P＜0.05)。100% RMD rice組之禁食血漿三酸甘油酯及總膽固醇濃度的降低量顯著高於RC組 (P＜0.05)。67% RMD rice 及100% RMD rice組之肝臟三酸甘油酯濃度顯著較RC組及33% RMD rice組低 (P＜0.05)。100% RMD rice組之肝臟膽固醇濃度顯著較其餘3組低 (P＜0.05)。33% RMD rice、67% RMD rice 及100% RMD rice組之糞便膽酸濃度顯著較RC組高 (P＜0.05)。隨每日難消化性麥芽糊精攝取量(0－2.7 g/d)的增加，第2型糖尿病大鼠之禁食血漿葡萄糖、胰島素、三酸甘油酯及總膽固醇濃度、胰島素抗性程度、肝臟三酸甘油酯及膽固醇濃度顯著隨之降低 (P＜0.05)。本研究結果顯示富含難消化性麥芽糊精熟飯可使第2型糖尿病大鼠之禁食血漿葡萄糖、胰島素、三酸甘油酯及總膽固醇濃度、胰島素抗性程度、肝臟三酸甘油酯及膽固醇濃度顯著降低，且降低之效果顯著與每日難消化性麥芽糊精攝取量呈正相關。

關鍵字

難消化性麥芽糊精 ； 第2型糖尿病大鼠 ； 胰島素抗性 ； 三酸甘油酯 ； 膽固醇

並列摘要

The purpose of this study was to examine the effects of resistant maltodextrin (RMD)-enriched boiled rice on carbohydrate and lipid metabolism in type 2 diabetic rats. Thirty-two male Wistar rats with streptozotocin/nicotinamide-induced type 2 diabetes were randomly divided into RC (rice control), 33% RMD rice, 67% RMD rice and 100% RMD rice groups. Four diets were modified from AIN-93M, and the starch of RC diet was totally from boiled rice without RMD, and the starch of 33% RMD rice, 67% RMD rice and 100% RMD rice diets were 33%, 67% and 100% from RMD-enriched boiled rice. Four groups were fed each diet for 4 weeks. The fasting plasma glucose and insulin levels in the rats fed the 100% RMD rice diet were significantly lower than that of RC group (P＜0.05). The levels of insulin resistance in the rats fed the 67% RMD rice and 100% RMD rice diets were significantly lower than that of RC group (P＜0.05). The levels of attenuation of fasting plasma triglyceride and total cholesterol in the rats fed the 100% RMD rice diet were significantly higher than that of RC group (P＜0.05). The hepatic triglyceride levels in the rats fed the 67% RMD rice and 100% RMD rice diets were significantly lower than that of RC and 33% RMD rice groups (P＜0.05). The hepatic cholesterol levels in the rats fed the 100% RMD rice diet were significantly lower than that of other groups (P＜0.05). The rats fed the 33% RMD rice, 67% RMD rice and 100% RMD rice diets had greater fecal bile acid excretion than the rats fed the RC diet (P＜0.05). The levels of fasting plasma glucose, insulin, triglyceride and total cholesterol, insulin resistance, hepatic triglyceride and cholesterol in the diabetic rats were negatively correlated with daily intake of resistant maltodextrin (0－2.7 g/d). These findings support the conclusion that RMD-enriched boiled rice can significantly suppress hyperglycemic and hyperlipidemic responses in type 2 diabetic rats, and the suppressive effect was positively correlated with daily intake of resistant maltodextrin.

並列關鍵字

resistant maltodextrin ； type 2 diabetic rats ； insulin resistance ； triglyceride ； cholesterol

參考文獻

行政院衛生署 (2008) 臺灣地區十大死因統計資料，行政院衛生署編印，臺北。

賴明宏 (2002) 飲食中補充米麩或三價鉻對第二型糖尿病患或STZ誘導的糖尿病大白鼠醣類及脂質代謝之影響。臺北醫學大學藥學研究所食品化學組博士論文。

American diabetes association (2003) Screening for type 2 diabetes. Diabetes Care 26: S21-S24.

Anderson JW, Chen WJ (1979) Plant fiber. Carbohydrate and lipid metabolism. Am J Clin Nutr 32: 346-363.

Banerjee M, Kanitkar M, Bhonde RR (2005) Approaches towards endogenous pancreatic regeneration. Rev Diabet Study 2: 165-176.