新型二元鈦基植體合金於牙科和生醫之應用與發展：高溫微觀結構特性和生物相容性評估

Development of the novel binary Ti-based implant alloy for dental and biomedical applications: High temperature microstructural characteristics and biocompatibility evaluation

黃彥衡(Yen-Heng Huang)

指導教授 ： 黃茂栓

臺北醫學大學/口腔醫學院/醫療器材產業碩士專班/碩士(2014年)

摘要

本研究主要針對Ti-10Ge合金經不同溫度之熱處理後，其顯微結構、機械特性與生物相容性進行研究。研究分析結果顯示；合金之晶粒大小隨熱處理溫度增加而變大，當Ti-10Ge合金經700°C至1000°C之熱處理後可發現一?? → (?? + Ti5Ge3)
之相變化過程。Ti-10Ge合金被熱處理於800°C後呈現相對高之微硬度約Hv 1151，且此合金試片亦被發現擁有親水性表面特徵。細胞毒性檢測亦證明經不同溫度熱處理後之Ti-10Ge合金試片並不會影響MG-63與NIH-3T3細胞之貼附與增生行為，此證據證明經不同溫度熱處理後之Ti-10Ge合金皆具有良好之生物相容性，故此Ti-10Ge合金係一有希望之可替換生醫材料可於生醫與牙科材料之應用。

關鍵字

Ti-10Ge 合金 ； 生物相容性 ； 顯微結構 ； 牙科植體

並列摘要

In this study, the Ti-10Ge alloy was conducted to investigate its microstructure, mechanical properties and biocompatibility after heat treated with different temperatures. The analytical results indicated that the grain size of the samples increased with increasing the heat treatment temperature. As the investigated alloy underwent heat treatment at temperatures between 700°C and 1000°C, the phase transformation sequence was found to be α → (α +Ti5Ge3). The microhardness of the T10G-2 sample exhibits the maximum Hv value around 1151. Moreover, T10G-2 sample was also found to possess the hydrophilic surface. These heat treated samples did not influence the cells adhesion and proliferation behaviors of MG-63 and NIH-3T3 cells in this range of heat treatment temperature. It is evident that the heat treated Ti-10Ge samples possessed the well biocompatibility. Therefore, the Ti-10Ge alloy is a promising substitute biomaterial for biomedical and dental applications.

並列關鍵字

Ti-10Ge alloy ； Biocompatibility ； Microstructure ； Dental implant

參考文獻

[1] M.N. Avula, A.N. Rao, L.D. McGill, D.W. Grainger, F. Solzbacher, Foreign body response to subcutaneous biomaterial implants in a mast cell-deficient Kit(w-sh) murine model, Acta Biomater, 10 (2014) 1856-1863.

[2] L. Bai, K.H. Zhan, Q. Hu, J.M. Xu, Endothelial tubes form from intracellular vacuoles in implanted biomaterial in vivo of rat, J Mater Sci-Mater M, 25 (2014) 1275-1282.

[3] S. Choudhury, S. Batabyal, T. Mondol, D. Sao, P. Lemmens, S.K. Pal, Ultrafast Dynamics of Solvation and Charge Transfer in a DNA- Based Biomaterial, Chem-Asian J, 9 (2014) 1395-1402.

[4] A. Conway, D.V. Schaffer, Biomaterial Microenvironments to Support the Generation of New Neurons in the Adult Brain, Stem Cells, 32 (2014) 1220-1229.

[5] S.F. Durao, P.S. Gomes, B.J. Colaco, J.C. Silva, H.M. Fonseca, J.R. Duarte, A.C. Felino, M.H. Fernandes, The biomaterial-mediated healing of critical size bone