檳榔子及大葉合歡樹皮單寧及其相關化合物之研究

Studies on Tannins and Related Compounds from Areca catechu L. and Albizzia lebbek (L.) Benth.

蕭淑珍(Shu Chen Hsiao)

指導教授 ： 徐鳳麟

臺北醫學大學/藥學院/藥學研究所/碩士(1994年)

摘要

檳榔(Areca catechu L.) 和大葉合歡[Albizzia lebbek (L.) Benth.] 為熱帶地區常見的常綠喬木，兩者均含有豐富的多酚性化合物 (polyphenolics)，因此本實驗室便以檳榔子及大葉合歡樹皮為研究對象 ，進行單寧 (tannin) 及相關化合物成分的探討，以期開發新的醫療資源 。藉由各種管柱層析法，從檳榔子中分離純化出五種化合物，根據物理數 據及光譜證據，其結構分別確認為(+)-catechin, (-)-epicatechin, procyanidin B-2, procyanidin B-7 以及epicatechin-(4β -8)-epicatechin (4β-8)-catechin. 此外，從大葉合歡樹皮中亦純化出 五種化合物，其結構分別判定為 (-)-epicatechin, procyanidin B-2, procyanidin B-5 , procyanidin C-1 及 gentisic acid 5-O -β- D -(5''''- O- 3'''''', 5''''''- dimethoxygalloyl ) apiofuranosyl (1'''' → 2'')-β-D-glucopyranoside， 其中最後 的化合物為文獻上尚未有記載之 新化合物。

關鍵字

單寧 ； 檳榔 ； 大葉合歡

並列摘要

Areca catechu L. (Palmae) and Albizzia lebbek (L.) Benth. (Leguminosae) are evergreen trees that spread all over the tropical areas and both of them are rich in polyphenolics. In our laboratory, we used the fresh unripe embryos of Areca catechu and the bark of Albizzia lebbek to study the compounds belong to tannin class and effort for developing these polyphenolic compounds to be a new and useful medicine in the future. By various column chromatographies five compounds were isolated and purified from the fresh unripe embryos of Areca catechu . Base on the analysis of physical and spectroscopic data, we characterized these compounds as (+)-catechin, (-)- epicatechin, procyanidin B-2, procyanidin B-7 and epicatechin -(4β-8)-epicatechin-(4β-8)-catechin. In addition, five compounds were obtained from the bark of Albizzia lebbek , the structures of these compounds were elucidated as (-)-epicatechin, procyanidin B-2, procyanidin B-5, procyanidin C-1 and 5-O-β-D-(5''''-O-3'''''',5''''''-dimethoxy- galloyl) apiofuranosyl (1''''→2'')-β-D-glucopyranoside. Above all, the last compound is a new natural product.

並列關鍵字

Tannin ； Areca catechu L. ； Albizzia lebbek (L.) Benth.