以動物實驗探討經陽極表面處理微型骨釘之癒合效果與穩固度評估

The evaluation of healing and stability of anodized mini-screw in animal study.

高俊義(Chun-Yi Kao)

指導教授 ： 楊正昌 ； 李勝揚 ； 蔡吉陽

臺北醫學大學/口腔學院/牙醫學系碩博士班/碩士(2005年)

摘要

陽極處理技術可以有效增加鈦金屬植體表面氧化膜厚與多孔性，有利於細胞貼覆及組織生長，增進骨組織生長的質與量，而有助於縮短骨整合所需的時間。本研究之目的在以體內試驗評估微型骨釘(mini-screw)經陽極處理後，對穩固度之影響。試驗採用尺寸分別為1.3 mm與1.5 mm之微型骨釘各12支，實驗對象為三隻雄性小獵犬(beagle)，植入位置為下顎無牙區處，施力前之等待癒合時間為0週、2週與6週三組，再以鎳鈦合金彈簧連接同組骨釘，控制施力約為200克，持續三個月，於動物犧牲後，以組織切片測量骨釘骨接觸程度。結果顯示，1.3 mm骨釘成功率為87.5% (10/12)，1.5 mm骨釘為100% (12/12)，前者骨接觸程度分別為37.57%（癒合0週）、78.52%（癒合2週）與47.73%（癒合6週），後者則分別為49.33%，59.08%與46.86%，皆高於先前文獻研究結果，陽極處理效果可能是影響的主因。為來發展上可結合陽極處理技術，縮短矯正骨釘臨床使用長度，使其兼具操作安全與穩固度佳之優點。

關鍵字

矯正 ； 陽極表面處理 ； 微型骨釘 ； 錨定

並列摘要

The porous oxide surface characterier of titanium alloy can be improved by the technology of anodization which benefits cell adhesion and tissue growth. It also accelerates the quality and quantity of bone growth that in terms helps to shorten the period of bone healing. The purpose of this study was to evaluate the effects of anodized mini-screws on the stability in vivo. The chosen sizes of the mini-screws were 1.3mm and 1.5mm. We used 12 each on three male beagle dogs. We selected edentulous areas for implantation and the time of healing before applying force were 0 week, 2 weeks, and 6 weeks respectively. Then we connected NiTi coil springs to the mini-screws in the same group and the magnitude of force was controlled at 200g. The histology was examined to measure bone-implant contact (BIC). The results showed that the success rates were 87.5%(10/12) for 1.3mm mini-screw and 100%(12/12) for 1.5mm. BIC of the former group were 37.57%(healing time 0 week), 78.52%(healing time 2 weeks), and 47.73%(healing time 6 weeks) respectively. The later one were 49.33%, 59.08%, and 46.86% respectively. These were all higher than previous studies. In the future development, we are hoping to combine this technology of anodization to shorten the length of mini-screws for clinical use in order to improve their safety and stability.

並列關鍵字

orthodontics ； anolized ； mini-screw ； anchorage

參考文獻

3. Umemori M, Sugawara J, Mitani h, nagasaka H, Kawamura H. Skeletal anchorage system for open-bite correction. Am J Orthod Dentofacial Orthop, 115: 166-174, 1999.

4. Sugawara J, Daimaruy T, ‘umemori M, Nagasaka H, Takahashi I, Kawamura H, Mitani H. Distal movement ofmandibular molars in adult patients with the skeletal anchorage system. Am J Orthod Dentofacial Orthop, 125(2): 130-138, 2004.

5. Keith HS, James B, William T. Intrusion of supererupted molars with titanium miniplate anchorage. Angle Orthod, 73: 597-601, 2003.

7. Miyawaki S, Koyama I, Inoue M, Mishima K, Sugahara T, Yamatoto TT. Factors associated with the stability of titanium screws placed in the posterior region for orthodontic anchorage. Am J Orthod Dentofacial Orthop, 124: 373-378, 2003.

9. Park HS. A new protocol of the sliding mechanics with micro-implant anchorage (MIA). Korea J orthod, 30(6): 677-685, 2000.