納豆萃取物對大鼠血液粘度及血脂質的影響

心血管相關疾病(cardiovascular disease, CVD) (腦血管疾病、心臟疾病及高血壓)仍居台灣地區十大死因之第二、三及第十名。動脈粥狀硬化是冠狀動脈心臟病、中風的原因。研究顯示亞洲人食用大豆相關製品具有較低的CVD發生率。納豆含有強纖維蛋白溶解能力的納豆激酶(Nattokinase；NK)。本實驗的目的是探討納豆萃取物對老鼠的血液粘度、血脂質、肝臟脂質及抗氧化酵素活性等心血管疾病危險因子的影響。70隻雄性之Sprague-Dawley (SD)大白鼠，隨機分為5組，負控制組食用正常飼料，正控制組及納豆組給予高脂/高膽固醇飲食。結果：中倍劑量納豆組(31.26 mg /天)血清介白質-6(IL-6)改變量顯著下降；高倍劑量納豆組(104.2 mg /天)攝食利用率顯著降低，而GSH/GSSG ratio與餵食週數呈顯著正相關；中及高倍劑量納豆組(31.26 mg, 104.2 mg /天)肝臟TC顯著下降。由本實驗得知食用未純化納豆萃取物，可降低血清IL-6及肝臟TC，對降低心血管疾病有正面的功效。

關鍵字

動脈粥狀硬化；納豆萃取物；納豆激酶血液黏度；總膽固醇

並列摘要

Cardiovascular diseases (CVD) including brain vascular disease, heart disease, and hypertensive still occupy the 2nd, 3rd, and 10th causes of death in Taiwan. Arteriosclerosis results in coronary heart disease (CHD) and stroke. According to the epidemiological researches, Asian people have lower incidence of CVD due to the consumption of soybean relative food. Nattos contain Nattokinase (NK) which is highly fibrinolytic activity. The aim of this experiment is to evaluate the effects of CVD risk factors in vivo by measuring whole blood viscosity (WBV), serum lipid, liver lipid, and antioxidant activity. Seventy 6-week-old male SD rats were divided into 5 groups randomly. Negative control group fed normal diets, positive control and natto groups fed high fat/high cholesterol diets. Results showed change of Interleukin-6 (IL-6) decreased singnifantly in the group fed (31.26mg/day) Natto. The feed efficiency decreased singnifantly while the GSH/GSSG ratio positively correlated to the period of feeding time in the group fed (104.2mg/day) Natto. The liver TC decreased singnifantly in the group fed (31.26mg, 104.2mg/day)Natto. In this study, the consumption of non-purified natto extract decreased IL-6 and liver TC, which is helpful in preventing CVD.

並列關鍵字

arteriosclerosis ； natto extract ； nattokinase ； whole blood viscosity ； total cholesterol

參考文獻

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納豆萃取物對大鼠血液粘度及血脂質的影響

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