Control charts are often used in manufacturing processes for monitoring the process changes. A control chart may indicate an out-of-control condition either when one or more points fall beyond the control limits, or when the plotted points exhibit some nonrandom pattern of behavior. In this research, we consider an alternative process monitoring approach based on artificial neural networks. The artificial neural network used in this research is a multi-layer network trained by back-propagation algorithm. We consider the quality characteristics expressed in terms of sample means or the rate of occurrences of events. The inputs of artificial neural networks consist of sample statistics and some heuristic indexes. Some critical design factors are determined by Taguchi''s experimental design. A discussion of design strategies is also provided. Extensive simulation results show that the proposed neural network-based procedures are superior to CUSUM control charts in terms of the average run lengths.