With rapid technological advances, manufacturing and design processes of cell-based design has become extremely complicated. Structured ASIC can potentially fill this gap [1]. Extensive research has proposed the design of basic cell in Structured ASIC for performance, area, and power issues [2][6]. If Structured ASIC is to become a viable alternative to cell-based design, it must deliver performance and energy efficiency which is competitive with cell-based design techniques. Supply voltage reduction is one of the most effective techniques in reducing power consumption of CMOS circuits. The total current to be delivered by the voltage supplies is significantly reduced in dual- or multiple- VDD circuits [3][7][9][10][14][15][22][23]. On-chip power distribution grids with multiple power supply voltages and multiple grounds are used for more flexible placement and routing[4][17][18]. In this thesis, we propose the design methodology of Structured ASIC using multiple supply voltage based on dual VDD power delivery model. We will describe issues such as VCLB of dual VDD delivery system, multiple supply voltage assignment algorithm, high speed level converter and flexible placement exploiting dual VDD delivery.