在聚乙二醇與水之體系中利用鈀催化苯胺類與烯丙酯類化合物進行烯丙基化反應研究

烯丙基胺類化合物在有機合成中不僅是反應中間體，同時也存在於自然界且擁有生物活性，因此是一個重要的化合物。而利用金屬鈀當作催化劑來進行烯丙基化反應，形成碳-碳鍵，碳-氮鍵和碳-氧鍵，在有機化學中是很廣泛的合成方法。聚乙二醇是一種在空氣中穩定、無毒性、便宜且對環境友善的物質，這對於目前提倡的綠色化學是很重要的。而醋酸鈀-水-聚乙二醇催化系統可廣泛的活化反應物是頗讓人印象深刻的，因此聚乙二醇可有效地促使鈀的催化進行反應。在本研究中，我們完成利用鈀催化劑，在水及聚乙二醇系統中，使苯胺類和乙酸烯丙酯類進行烯丙基化反應，並探討各苯胺類反應物之結果。

關鍵字

鈀；乙烯基化反應；聚乙二醇

並列摘要

Allyl amines are an important class of compounds not only due to their utility as intermediates in organic synthesis but also because of their physiological properties and their presence in several natural products.The palladium-catalyzed allylation is a powerful tool for C-C, C-N, and C-O bond formation, which has been widely applied to organic chemistry. Poly(ethylene glycol) was air stable, nontoxic, inexpensive and environmentally friendly. It is important in green chemistry. The Pd(OAc)2-H2O-PEG system are impressive activating for a wide range of substrates.Therefore, palladium catalyzed reactions with PEG has been carried out. In this study, we carried out the allylation of anilines with allylic acetates in PEG-H2O system in the presence of palladium as catalyst. N-allylation of anilines was achieved.